Persistent cytomegalovirus infection--the etiology of Sjogren's syndrome
Burns, J.C.
Medical Hypotheses 10(4): 451-460
1983
ISSN/ISBN: 0306-9877
PMID: 6308404
DOI: 10.1016/0306-9877(83)90011-7
Accession: 043919787
The persistence of Cytomegalovirus (CMV) with alteration of cell surface expression in certain tissues may initiate the tissue destruction that leads to the clinical manifestations of Sjogren's Syndrome. Salivary gland and lacrimal gland ductal cells are immunologically attacked due to CMV antigenic expression. The destruction of these ducts leads to xerostomia and keratonconjunctivitis sicca, the hallmarks of Sjogren's Syndrome.
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