+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Plasma concentrations and beta-blocking effects in normal volunteers after intravenous doses of metoprolol and propranolol



Plasma concentrations and beta-blocking effects in normal volunteers after intravenous doses of metoprolol and propranolol



Journal of Cardiovascular Pharmacology 2(6): 715-723



The pharmacokinetics of metoprolol and propranolol in 6 healthy volunteers were compared after an intravenous dose of 10 mg of each drug. The mean t1/2, beta was 3.6 hr for both drugs, but due to a larger volume of distribution, the total body clearance was significantly higher for metoprolol (1.20 liters/min) than for propranolol (0.81 liters/min). The individual pharmacokinetic data were used to calculate the doses required to increase the amount of each drug in the body to 10 and 20 mg at 90 and 180 min respectively after an initial intravenous dose of 5.0 mg. The effect on exercise heart rate was determined 30 min after each dose. After identical doses, the two drugs had similar beta-blocking effects in terms of reducing exercise-induced tachycardia. These effects increased with the dose administered. The plasma levels of propranolol were twice as high as those of metoprolol for identical degrees of beta-blockade. The slope of the regression line for the relationship between the beta-blocking effect and log plasma concentrations was the same for the two drugs.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 043959467

Download citation: RISBibTeXText

PMID: 6160322

DOI: 10.1097/00005344-198011000-00002


Related references

The effects of beta blocking agents metoprolol and propranolol on the hemodynamics and plasma catecholamines during exercise. Kitakanto Medical Journal 38(4): 211-224, 1988

Pre-dosing plasma concentrations and beta-adrenoceptor blocking effects during repeated once daily dosing with 160 mg sustained-release propranolol (Inderal LA) and 16/260 oxprenolol Oros to healthy volunteers. British Journal of Clinical Pharmacology 19 Suppl 2: 197s-201s, 1985

Pre dosing plasma concentrations and beta adrenoceptor blocking effects during repeated once daily dosing with 160 milligram sustained release propranolol inderal la and 16 260 oxprenolol oros to healthy volunteers. British Journal of Clinical Pharmacology 19(SUPPL 2): 197S-202S, 1985

Influence of beta-adrenoceptor blockade by metoprolol and propranolol on plasma concentrations and effects of noradrenaline and adrenaline during i.v. infusion. Acta Physiologica Scandinavica. Supplementum 515: 45-53, 1983

Influence of beta adrenoceptor blockade by metoprolol and propranolol on plasma concentrations and effects of noradrenaline and adrenaline during intra venous infusion. Acta Physiologica Scandinavica Suppl. (515): 45-54, 1983

Plasma concentrations, hemodynamic effects and beta-receptor blocking effect of optic isomers of propranolol (Dociton). Verhandlungen der Deutschen Gesellschaft für Innere Medizin 80: 260-263, 1974

Haemodynamic effects of the beta-receptor blocking agents metoprolol and propranolol in the anesthetized dog. Klinische Wochenschrift 56 Suppl 1: 107-112, 1978

Haemodynamic effects of the beta-receptor blocking agents metoprolol and propranolol in the anaesthetized dog. Journal of Molecular Medicine 56(1 Suppl.): 107-112, 1978

Comparative beta blocking potencies of oral propranolol and labetalol in normal volunteers. Clinical Research 33(2 PART 1): 280A, 1985

Chronopharmacokinetics of beta-receptor blocking drugs of different lipophilicity (propranolol, metoprolol, sotalol, atenolol) in plasma and tissues after single and multiple dosing in the rat. Naunyn-Schmiedeberg's Archives of Pharmacology 330(1): 42-49, 1985

Pharmaco kinetics of beta adrenoceptor blocking drugs of different polarity propranolol metoprolol atenolol in plasma and various organs of the light dark synchronized rat. Naunyn-Schmiedeberg's Archives of Pharmacology 316(SUPPL): R60, 1981

The comparative beta-adrenoceptor blocking effects of penbutolol, atenolol and sustained-release metoprolol in healthy volunteers. European Journal of Clinical Pharmacology 27(3): 269-273, 1984

The effects of selective and nonselective beta blocking agents in patients with asthma studies on metoprolol practolol and propranolol and their interaction with isoprenaline. Blondheim, S H (Ed ) Frontiers Of Internal Medicine, 1974 Twelfth International Congress Tel Aviv, Israel, Sept 8-13, 1974 Xxi+433p Illus S Karger: Basel, Switzerland; New York, N Y , U S A ISBN 3-8055-2205-3: 230-235, 1975

Effects on intravenous - and -propranolol on plasma concentrations of - and -propranolol. Clinical Pharmacology & Therapeutics 63(2): 232, 1998

Acute effects of propranolol and metoprolol on plasma concentrations of parathyroid hormone and calcitonin in uraemic patients. Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association 16: 649-655, 1979