+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Protection against reactive oxygen species by NAD(P)H: quinone reductase induced by the dietary antioxidant butylated hydroxyanisole (BHA). Decreased hepatic low-level chemiluminescence during quinone redox cycling



Protection against reactive oxygen species by NAD(P)H: quinone reductase induced by the dietary antioxidant butylated hydroxyanisole (BHA). Decreased hepatic low-level chemiluminescence during quinone redox cycling



Febs Letters 169(1): 63-66



Menadione elicits low-level chemiluminescence (lambda greater than 620 nm) associated with redox cycling of the quinone in mouse hepatic postmitochondrial fractions. This photoemission is suppressed when the animals are fed a diet containing the anticarcinogenic antioxidant, 2[3]-(tert-butyl)-4-hydroxyanisole (BHA), which leads to a 13-fold increase in NAD(P)H: quinone reductase (EC 1.6.99.2). Inhibition of the enzyme by dicoumarol completely abolishes the protective effect of BHA treatment and leads to higher chemiluminescence, reaching similar photoemission for BHA-treated and control animals. These findings indicate that the two-electron reduction promoted by quinone reductase prevents redox cycling and that BHA protects against reactive oxygen species by elevating the activity of this enzyme.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 044074700

Download citation: RISBibTeXText

PMID: 6201394


Related references

In cellulo monitoring of quinone reductase activity and reactive oxygen species production during the redox cycling of 1,2 and 1,4 quinones. Free Radical Biology and Medicine 89: 126-134, 2015

Hepatic low-level chemiluminescence during redox cycling of menadione and the menadione-glutathione conjugate: relation to glutathione and NAD(P)H:quinone reductase (DT-diaphorase) activity. Archives of Biochemistry and Biophysics 224(2): 568-578, 1983

Chemiluminescence assay for quinones based on generation of reactive oxygen species through the redox cycle of quinone. Analytical and Bioanalytical Chemistry 393(4): 1337-1343, 2009

Detoxification by quinone reductase of reactive intermediates generated during redox cycling of estrogen. Proceedings of the American Association for Cancer Research Annual Meeting 28: 123, 1987

The peroxidase-dependent activation of butylated hydroxyanisole and butylated hydroxytoluene (BHT) to reactive intermediates. Formation of BHT-quinone methide via a chemical-chemical interaction. Journal of Biological Chemistry 264(7): 3957-3965, 1989

Rat liver NAD(P)H:quinone reductase. Construction of a quinone reductase cDNA clone and regulation of quinone reductase mRNA by 3-methylcholanthrene and in persistent hepatocyte nodules induced by chemical carcinogens. Journal of Biological Chemistry 261(12): 5524-5528, 1986

Role of glutathione and nadph quinone oxido reductase dt diaphorase in determining low level chemi luminescence during redox cycling of menadione. Bors, W , M Saran And D Tait (Ed ) Oxygen Radicals in Chemistry And Biology; Proceedings Of The 3rd International Conference, Neuherberg, West Germany, July 10-15, 1983 Xix+1029p Walter De Gruyter: Berlin, West Germany; New York, N Y , Usa Illus P331-334, 1984

Ultrasensitive determination of pyrroloquinoline quinone in human plasma by HPLC with chemiluminescence detection using the redox cycle of quinone. Journal of Pharmaceutical and Biomedical Analysis 145: 814-820, 2017

Ellagic acid induces NAD(P)H:quinone reductase through activation of the antioxidant responsive element of the rat NAD(P)H:quinone reductase gene. Carcinogenesis 15(9): 2065-2068, 1994

Induction of heme oxygenase-1 (HO-1) and NAD[P]H: quinone oxidoreductase 1 (NQO1) by a phenolic antioxidant, butylated hydroxyanisole (BHA) and its metabolite, tert-butylhydroquinone (tBHQ) in primary-cultured human and rat hepatocytes. Pharmaceutical Research 23(11): 2586-2594, 2006

The role of redox cycling versus arylation in quinone-induced mitochondrial dysfunction: a mechanistic approach in classifying reactive toxicants. SarandQsarinEnvironmentalResearch4(2-3):97, 1995

Acceleration of azo dye decolorization by using quinone reductase activity of azoreductase and quinone redox mediator. Bioresource Technology 100(11): 2791-2795, 2009

Aldo-keto reductase 1C15 as a quinone reductase in rat endothelial cell: its involvement in redox cycling of 9,10-phenanthrenequinone. Free Radical Research 45(7): 848-857, 2011

A Redox-Based Superoxide Generation System Using Quinone/Quinone Reductase. Chembiochem 19(15): 1657-1663, 2018

Lack of quinone reductase activity suggests that amyloid-beta peptide/ERAB induced lipid peroxidation is not directly related to production of reactive oxygen species by redoxcycling. Toxicology 144(1-3): 163-168, 2000