+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Protective activity of extracts from Salmonella-R-mutants against Salmonella typhimurium infection in mice. Influence of repeated extractions on the chemical composition and efficacy of the extracts



Protective activity of extracts from Salmonella-R-mutants against Salmonella typhimurium infection in mice. Influence of repeated extractions on the chemical composition and efficacy of the extracts



Zentralblatt für Bakteriologie Mikrobiologie und Hygiene. 1. Abt. Originale A Medizinische Mikrobiologie Infektionskrankheiten und Parasitologie 251(2): 196-202



Repeated extractions (three times) of an S-form and different R-mutants of S. typhimurium and S. minnesota with urea medium resulted in extracts varying in their chemical composition with respect to protein, lipopolysaccharides, phospholipids and nucleic acids. Protein appeared to be the major component of all the extracts and was present in substantial amounts in the third extract also. With subsequent extractions the lipopolysaccharide and phospholipid contents generally decreased in the R-mutants, but increased in the S-form. The nucleic acid contents always increased with repeated extractions. polypeptide patterns of the materials obtained after repeated extraction showed some differences in case of R-mutants predominantly. Active immunization of mice with these extracts protected them almost to the same extent against S. typhimurium infection. Only in case of one R-mutant a graded decrease in protection could be observed from extract 1 to extract 3. However, the differences in composition of the vaccines based on chemical analysis data and polypeptide pattern could not account for this decrease in protection.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 044075545

Download citation: RISBibTeXText

PMID: 6176087


Related references

Immunization against salmonella typhimurium infection in mice. Chemical composition and protecting activity of different extracts from salmonella R mutants. Zentralblatt für Bakteriologie. 1. Abt. Originale. A: Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie 248(1): 64-80, 1980

Osmotic shock fluids from salmonella r mutants chemical composition and protective capacity against salmonella typhimurium infection in mice. Zentralblatt fuer Bakteriologie Mikrobiologie und Hygiene 1 Abt Originale A 252(3): 347-354, 1982

Osmotic shock fluids from salmonella R-mutants. Chemical composition and protective capacity against S. typhimurium infection in mice. Zentralblatt für Bakteriologie Mikrobiologie und Hygiene. 1. Abt. Originale A Medizinische Mikrobiologie Infektionskrankheiten und Parasitologie 252(3): 347-354, 1982

Immunity to experimental salmonella infection studies of the protective capacity and immunogenicity of lipo poly saccharide acetone killed cells and ribosome rich extracts of salmonella typhimurium in c 3h hej and cd 1 mice. Journal of Immunology 121(3): 1010-1014, 1978

Protection against salmonella typhimurium infection in mice immunoenhancing activity of heterologous salmonella s forms r mutants lipopolysaccharides and muramyl dipeptide used in combination with salmonella typhimurium as mixed vaccines. Zentralblatt fuer Bakteriologie Mikrobiologie und Hygiene Series A 257(3): 414-425, 1984

Protective immunization with salmonella r mutants against salmonella typhimurium infection in experiments with mice. Zentralblatt fuer Bakteriologie Parasitenkunde Infektionskrankheiten und Hygiene Erste Abteilung Originale Reihe A Medizinische Mikrobiologie und Parasitologie 227(1-4): 250-256, 1974

Protection against experimental Salmonella typhimurium infection in mice. Immunostimulating activity of heterologous Salmonella S-forms, R-mutants, lipopolysaccharides and muramyl dipeptide in vaccines combined with S. typhimurium. Zentralblatt für Bakteriologie Mikrobiologie und Hygiene. Series A Medical Microbiology Infectious Diseases Virology Parasitology 257(3): 414-425, 1984

Studies on immunogenicity and protective efficacy of DnaJ of Salmonella Typhi against lethal infection by Salmonella Typhimurium in mice. Vaccine 24(49-50): 7135-7141, 2006

Protective action on mice of acellular extracts from Salmonella typhimurium. Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences. Serie D: Sciences Naturelles 286(22): 1633-1635, 1978

Protective effects of a supernatant factor from Salmonella typhimurium on Salmonella typhimurium infection of inbred mice. Infection and Immunity 22(1): 125-131, 1978

Toxicity of lipopolysaccharide and of soluble extracts of Salmonella typhimurium in mice immunized with a live attenuated aroA salmonella vaccine. Infection and Immunity 62(6): 2285-2288, 1994

Experimental protective immunization of mice against S. typhimurium infection by Salmonella R mutants. Zentralblatt für Bakteriologie Parasitenkunde Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie 227(1-4): 250-256, 1974

Immunogenicity and Cross-Protective Efficacy Induced by Outer Membrane Proteins from Salmonella Typhimurium Mutants with Truncated LPS in Mice. International Journal of Molecular Sciences 17(3): 416, 2016

Outer membrane vesicles derived from Salmonella Typhimurium mutants with truncated LPS induce cross-protective immune responses against infection of Salmonella enterica serovars in the mouse model. International Journal of Medical Microbiology 306(8): 697-706, 2016

Protective role of Salmonella R mutants in Salmonella infection in mice. Zentralblatt für Bakteriologie Parasitenkunde Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie 245(1-2): 71-88, 1979