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Pyrimidine derivatives. VI. Studies on the syntheses of orotic acid, uracil and pyrimido(5,4-d)pyrimidine derivatives


, : Pyrimidine derivatives. VI. Studies on the syntheses of orotic acid, uracil and pyrimido(5,4-d)pyrimidine derivatives. Yakugaku Zasshi 92(7): 785-795



Accession: 044108501

PMID: 4676215

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Related references

Mizoguchi M., 1972: Pyrimidine derivatives part 6 studies on the syntheses of orotic acid uracil and pyrimido 5 4 d pyrimidine derivatives. Yakugaku Zasshi: 785-795

Imai, K.; Ishida, T.; Horiguchi, H.; Ozasa, T.; Ohono, M.; Kawahara, S.; Murakami, M., 1976: Studies on the syntheses of sulfur containing pyrimido 5 4 d pyrimidine derivatives part 1 syntheses of pyrimido 5 4 d pyrimidine derivatives possessing methylsulfonyl or sulfonamide group at 2 position. Thirty-one kinds of pyrimido[5,4-d]pyrimidine derivatives possessing methylsulfonyl or sulfonamide group at 2-position were prepared by the reaction of 4,8-disubstituted 6-chloro-2-methylsulfonylpyrimido[5,4-d]pyrimidine or 4,8-disubstituted 6-chl...

Imai, K.; Ishida, T.; Horiguchi, H.; Ozasa, T.; Ohono, M., 1976: Studies on the syntheses of sulfur containing pyrimido [5,4-d]pyrimidine derivatives. I. Syntheses of pyrimido [5,4-D]pyrimidine derivatives possessing methylsulfonyl or sulfonamide group at 2-position. Yakugaku Zasshi 96(5): 578-585

Imai, K.; Ishida, T.; Ozasa, T.; Kawahara, S.; Murakami, M., 1976: Studies on the syntheses of sulfur containing pyrimido 5 4 d pyrimidine derivatives part 2 syntheses and rearrangement of 2 methylsulfonyl pyrimido 5 4 d pyrimidine 6 sulfonamide derivatives. In order to examine the relation between the structure and the activity of coronary vasodilation and inhibition of platelet aggregation [in dogs], 9 kinds of 2-methylsulfonylpyrimido-[5,4-d]pyrimidine derivatives possessing a sulfonamide group at...

Imai, K.; Ishida, T.; Ozasa, T.; Kawahara, S.; Murakami, M., 1976: Studies on the synthesis of sulfur containing pyrimido [5,4-d]pyrimidine derivatives. II. Syntheses and rearrangement of 2-methylsulfonyl pyrimido[5,4-d]pyrimidine-6-sulfonamide derivatives. Yakugaku Zasshi 96(5): 586-592

Imai, K.; Kojima, T.; Tamazawa, K.; Takahashi, K.; Kawahara, S., 1976: Studies on the syntheses of sulfur containing pyrimido [5,4-d]pyrimidine derivatives. IV. The mechanism of dipyridamole formation from 4,8-dipiperidino-pyrimido [5,4-d]pyrimidine-2,6-disulfonyl dichloride and diethanolamine. Yakugaku Zasshi 96(5): 600-607

Okada, J.; Nakano, K.; Miyake, H., 1983: Uracil derivatives. IV. Growth-inhibitory activity against L-1210 cells of orotic acid derivatives and synthesis of 1-(beta-D-ribofuranosyl)furo[3,4-d]pyrimidine-2,4,7(1H,3H,5H)-trione. Chemical & Pharmaceutical Bulletin 31(9): 3074-3083

Okada, J.; Nakano, K.; Miyake, H., 1983: Uracil derivatives 4. growth inhibitory activity against l 1210 cells of orotic acid derivatives and synthesis of 1 beta d ribo furanosyl furo 3 4 d pyrimidine 2 4 7 1h 3h 5h trione. 5-(Substituted thiomethyl)-6-carbamoyluracils and 5-(substituted thiomethyl)-uracils were prepared; their ability to inhibit the growth of L-1210 [mouse leukemia] cells in vitro was examined. The reaction of silylated furo[3,4-d]pyrimidine-2,4,7(1...

Yurugi S.; Miyake A.; Tada N., 1973: Studies on the syntheses of n hetero cyclic compounds part 18 syntheses of di substituted amino 2 phenyl pyrimido pyrimidine derivatives. Journal of Takeda Research Laboratories 32(3): 251-258

Hirota, K.; Yamada, Y.; Tetsuji, A.; Senda, S., 1982: Pyrimidine derivatives and related compounds 41. reactions of 1 3 6 tri methyl 5 nitro uracil and its 6 bromomethyl analog with amines and hydrazines synthesis of pyrazolo 4 3 d pyrimidine n oxides and their ring expansion to pyrimido 5 4 d pyrimidines. Reactions of 1,3,6-trimethyl-5-nitrouracil and 6-bromomethyl-1,3-dimethyl-5-nitrouracil with amines and hydrazines were studied with the aim of synthesizing fused-ring pyrimidines.