+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Radionuclide analysis of ejection time, peak ejection rate, and time to peak ejection rate: response to supine bicycle exercise in normal subjects and in patients with coronary heart disease



Radionuclide analysis of ejection time, peak ejection rate, and time to peak ejection rate: response to supine bicycle exercise in normal subjects and in patients with coronary heart disease



American Heart Journal 105(5): 802-810



Using equilibrium radionuclide angiography, we evaluated the ejection time (ET), peak ejection rate (PER), and time to peak ejection rate (TTp) at test and during supine bicycle exercise in 39 subjects, divided into three groups: group 1 = 13 normal subjects; group 2 = 10 patients with a previous infarction (MI); and group 3 = 16 patients with coronary disease without a previous MI. Normal subjects had greater ejection fractions and PERs than the other two groups at rest or peak exercise (p less than 0.05). PER was no more useful than ejection fraction in identifying cardiac dysfunction at either rest or exercise. The time of its occurrence varied with the group studied, and was slightly but significantly later in systole in groups 2 and 3 when compared to normals (p less than 0.05), though substantial overlap between groups occurred. During exercise, absolute ET shortened in all groups, but actually increased as a function of the R-R interval. The time to peak ejection rate (normalized for the R-R interval) was greater in the noninfarct group (group 3) patients (p less than 0.05) when compared to the group 1 or group 2 individuals at peak exercise. In conclusion, equilibrium radionuclide angiography is a useful technique for the quantification and characterization of events during systole, and is capable of providing information on the timing of events during ejection. Tardokinesis, or the delay of ventricular ejection, is not seen in the response of global indices of left ventricular function to exercise stress. While global early systolic indexes may not detect regional dyssynchrony, their timing during stress may occasionally aid in discerning the presence of cardiac dysfunction.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 044133453

Download citation: RISBibTeXText

PMID: 6846124

DOI: 10.1016/0002-8703(83)90244-2


Related references

Radionuclide analysis of peak filling rate, filling fraction, and time to peak filling rate. Response to supine bicycle exercise in normal subjects and patients with coronary disease. American Journal of Cardiology 51(1): 43-51, 1983

Left-ventricular peak ejection rate, filling rate, and ejection fraction--frame rate requirements at rest and exercise: concise communication. Journal of Nuclear Medicine 20(3): 189-193, 2013

Rate of change of left ventricular ejection fraction during exercise is superior to the peak ejection fraction for predicting functionally significant coronary artery disease. British Heart Journal 70(6): 507-512, 1993

Profiles of radionuclide left ventricular ejection fraction changes induced by supine bicycle exercise in normals and patients with coronary heart disease. Catheterization and Cardiovascular Diagnosis 5(4): 305-317, 1979

Reproducibility of equilibrium radionuclide ventriculography in patients with coronary artery disease: response of left ventricular ejection fraction and regional wall motion to supine bicycle exercise. American Heart Journal 104(3): 567-574, 1982

Postoperative evaluation of left ventricular peak filling rate and peak ejection rate by radionuclide ventriculography for aortic regurgitation. Nihon Kyobu Geka Gakkai 40(3): 375-381, 1992

Left ventricular ejection fraction during supine and upright exercise in patients with systemic hypertension and its relation to peak filling rate. American Journal of Cardiology 76(1): 61-65, 1995

Influence of heart rate increase on uncorrected pre-ejection period/left ventricular ejection time (PEP/LVET) ratio in normal individuals. British Heart Journal 38(7): 683-688, 1976

Superiority of supine bicycle over isometric handgrip exercise in the assessment of ischemic heart disease an evaluation of left ventricular ejection fraction response using radionuclide angiography. Clinical Cardiology 7(10): 547-553, 1984

Left ventricular function at rest and during exercise: assessment of ejection fraction, ejection rate and filing rate with radionuclide ventriculography. Herz 5(3): 159-167, 1980

Detecting coronary artery disease by radionuclide ventriculography: ejection time versus ejection fraction. Acta Cardiologica 43(3): 335-340, 1988

Ejection fraction and heart rate correlate with diastolic peak filling rate at rest and during exercise. Chest 88(1): 107-113, 1985

Comparison of the ejection time-heart rate relationships in normal and ischemic subjects. Japanese Heart Journal 6(6): 497-510, 1965

Blood pressure response to exercise predicts the survival rate more accurately than ejection fraction or peak VO2 in patients with dilated cardiomyopathy of age less than 50 years. Circulation 100(18 SUPPL ): I 443, Nov 2, 1999

Significant correlation between ratio of brachial pre-ejection period to ejection time and left ventricular ejection fraction and mass index in patients with chronic kidney disease. Nephrology, Dialysis, Transplantation 26(6): 1895-1902, 2011