Reactivity of the DOPA--dopamine--noradrenaline--adrenaline system in epileptics

Karlov, V.A.; Gleĭzer, M.A.

Zhurnal Nevropatologii i Psikhiatrii Imeni S.S. Korsakova 83(6): 810-815

1983


ISSN/ISBN: 0044-4588
PMID: 6410626
Accession: 044147811

Download citation:  
Text
  |  
BibTeX
  |  
RIS

Article/Abstract emailed within 1 workday
Payments are secure & encrypted
Powered by Stripe
Powered by PayPal

Abstract
Epileptic patients were examined for the daily urine elimination of DOPA, dopamine (DA), noradrenaline (NA), and adrenaline (A). The changes in the excretion of these substances after L-DOPA intake and the adrenaline and insulin test were also investigated. In addition to the evidence about the preserved reactivity of the DOPA-DA-NA-A system to L-DOPA intake, data were obtained pointing to its strain and a reduction in the reserve potentialities. The use of the adrenaline test disclosed the absence of, or a negative response on the part of DA and A in half of the patients, which correlated with definite clinical parameters. In one third of the patients, the insulin test was not accompanied by any increase in the excretion of A or its precursors. The findings obtained are indicative of the insufficiency of homeostatic reactions in epileptics and, possibly, of the deficit of the repolarizing mechanisms.