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Reduction of milk secretion by prolactin-inhibiting factor: further evidence that exteroceptive stimuli can release pituitary prolactin in rats



Reduction of milk secretion by prolactin-inhibiting factor: further evidence that exteroceptive stimuli can release pituitary prolactin in rats



Endocrinology 81(5): 1021-1028



Rat mammary glands were emptied of milk by pups suckling after an exogenous oxytocin injection into the mother. The pups were removed for 16 h and then returned to suckle; the milk yield was estimated from the weight gain of the pups and the weight loss of the mothers. The injection of either crude extracts of rat stalk-median eminence (SME) or a purified preparation of ovine prolactin-inhibiting factor (PIF) before the 1st suckling resulted in a significant drop in milk yield. Restoration of normal milk yields in SME-treated rats could be effected by the injection of prolactin and also in PIF-treated animals by placing the pups under, but not in contact with, the mothers. The latter effect presumably was the result of exteroceptive stimulation of prolactin release.

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Accession: 044165363

Download citation: RISBibTeXText

PMID: 4861217

DOI: 10.1210/endo-81-5-1021



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