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Regulation of human B cell proliferation by prostaglandin E2


, : Regulation of human B cell proliferation by prostaglandin E2. Journal of Immunology 133(5): 2446-2453

The role of prostaglandin E2 (PGE2) in the regulation of human B cell proliferation in vitro was examined. Initial studies demonstrated that monocyte (M phi)-mediated suppression of B cell proliferation in Staphylococcus aureus (SA)-stimulated cultures was diminished by indomethacin, and thus it was suggested that cyclooxygenase pathway products of arachidonic acid played a role in the regulation of B cell activation. The possibility that PGE2, one of the major products of this pathway generated by M phi, affected human B cell responses was therefore investigated. PGE2 was found to suppress B cell DNA synthesis and proliferation stimulated by SA in the presence or absence of B cell growth factor (BCGF)-containing T cell supernatants. Suppression was concentration-dependent; significant inhibition was observed in indomethacin-blocked cultures with 10(-10) to 10(-9) M PGE2. In contrast to the effect of PGE2 on SA-induced B cell proliferation, it had minimal effect on pokeweed mitogen (PWM)-stimulated B cell or T cell DNA synthesis. The effect of PGE2 on the generation of BCGF activity from mitogen-stimulated T cells was also examined. PGE2 (10(-7) M) did not inhibit the production of BCGF activity from PWM-stimulated T cells, or from T cells stimulated with the combination of phytohemagglutinin and phorbol myristate acetate. Thus, PGE2 inhibits B cell proliferation in response to SA but not PWM, and has little effect on the production of BCGF by T cells. These results indicate that PGE2 at physiologically relevant concentrations exerts selective regulatory effects on human B cell responses.

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Accession: 044174440

PMID: 6332851

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Albignac, R.; Blancou, J., 1970: Sur la reproduction et sur la pathologie des animaux au parc zoologique de Tsimbazaza centre ORSTOM de Tananarive. Bulletin Madagascar, 292, 738-749

Morton, Ar; Hercz, G., 1997: Calcium, phosphorus, and vitamin D metabolism in renal disease and chronic renal failure. Nutritional management of renal disease 367

Corapcioglu M. Yavuz; Bear Jacob, 1983: A mathematical model for regional land subsidence due to pumping; 3, Integrated equations for a phreatic aquifer. Following the development of a three-dimensional mathematical model consisting of a mass conservation equation, quasi-static equilibrium equations, and stress-strain relations for an assumed perfectly elastic solid matrix, a regional, horizontal t...

Mccune-Nicolich, L., 1982: Play as prelinguistic behavior: theory, evidence and applications. Infant communication development assessment and intervention edited by Dan P McClowry Arthur M Guilford Sylvia O Richardson: 1

Herman R.; Obarzanek E.; Mikalauskas K.M.; Post R.M.; Jimerson D.C., 1991: The effects of carbamazepine on resting metabolic rate and thyroid function in depressed patients. Resting metabolic rate and thyroid hormone levels were studied in 11 patients with affective disorders before and during treatment with carbamazepine (CBZ). CBZ has been previously reported to reduce thyroid hormones, but the metabolic consequence...

S.A. SANNI, 2012: Stability of iron-fortified gari during storage in different packaging materials. Gari a West African staple food, was fortified with 25, 35 and 45 mg/kg iron sulfate, iron fumarate and sodium iron ethylenediaminetetraacetic acid (NaFeEDTA), respectively. The fortified gari samples were packed in high-density zip-lock polyethy...

Nitz, Katherine; Smith, Kevin; Cox, Susan; Losasso, Barry; Chadwick, David; Kurtin, Paul, 1999: Patterns of unintentional and intentional injury at a regional pediatric trauma center 1993-1997. Pediatric Research 45(4 PART 2): 82A, April

Moorthy, R. S.; Buddi, R.; Smith, R. E.; Rao, N. A., 1994: The prevalence and management of cataracts in Vogt-Koyanagi-Harada syndrome. Investigative Ophthalmology & Visual Science 35(4): 1970

Baldauf, Richard J.; Lord, Rexford D., 1954: Another noteworthy range extension of the toad Bufo punctatus in Texas. The capture of a 70 mm. male specimen on old Highway No. 6, 3 miles s. of College Station, Brazos County, Texas on April ,28, 1953 extends the range of the species approximately 40 miles to the east.

Estrade, Marielle; Grondin, Pascal; Cluzel, Jacques; Bonhomme, Brigitte; Doly, Michel, 1998: Effect of a cGMP-specific phosphodiesterase inhibitor on retinal function. Multiple forms of phosphodiesterase have been reported in many tissues. Phosphodiesterase 6, a cGMP-specific phosphodiesterase, is described as a photoreceptor cell-specific phosphodiesterase. Phosphodiesterase 6 is known to play a crucial role in...