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Regulation of hydroxylation in position 21 of steroids in adrenal cortex cells of newborn rats, in culture. Utilization of aminoglutethimide and of exogenous steroids



Regulation of hydroxylation in position 21 of steroids in adrenal cortex cells of newborn rats, in culture. Utilization of aminoglutethimide and of exogenous steroids



Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales 178(1): 84-91



The use of aminoglutethimide at 5.10(-4) mol/l, inhibitor of endogenous steroidogenesis, and of exogenous progesterone (20 micrograms/ml) as substrate allowed the control of the steroid 21-hydroxylating reaction in cultured newborn rat adrenocortical cells. This method has been employed to show that the 21-hydroxylation by these cells is strongly induced by the adrenocorticotropic hormone (20 mU/ml).

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Accession: 044174513

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PMID: 6234975


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