EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
EurekaMag PDF Full Text Supply ServicePDF Full Text Supply Service
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn
Follow on LinkedInFollow on Tumblr

+ Translate

Regulation of immune response by autogenous antibody against receptor


, : Regulation of immune response by autogenous antibody against receptor. Proceedings of the National Academy of Sciences of the United States of America 71(12): 5083-5087

BALB/c mice repeatedly immunized with Pneumococcus R36A vaccine produce antibodies to phosphorylcholine having the TEPC-15 myeloma idiotype (murine IgA myeloma protein that binds phosphorylcholine). The plaque-forming cell response to phosphorylcholine shows a decrease with repeated immunizations. In contrast, spleen cells from multiply immunized mice responded better in vitro than spleen cells from nonimmunized mice. The serum of animals immunized four or five times agglutinates TEPC-15-coated sheep erythrocytes. Inhibition of hemagglutination shows that the agglutinating activity is directed against the TEPC-15 idiotype. Sera from these mice, when added to cultures of normal spleen cells, specifically suppress the response to phosphorylcholine. The suppressive activity in the serum can be removed by solid absorption with TEPC-15. Evidently, repeated immunization with antigen induces two kinds of antibody responses: one directed against antigen and the other directed against the antibody to the antigen. It is proposed that this "auto" antibody against receptor is involved in the regulation of the immune response.

(PDF same-day service: $19.90)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 044174529

PMID: 4140517

DOI: 10.2307/63974

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Ma, M.A.; Kumar, R.; Macey, P.M.; Yan-Go, F.L.; Harper, R.M., 2016: Epiglottis cross-sectional area and oropharyngeal airway length in male and female obstructive sleep apnea patients. Nature and Science of Sleep 8: 297-304

Filpula, D.; Nagle, J.W.; Pulford, S.; Anderson, D.M., 1988: Sequence of L-asparaginase gene from Erwinia chrysanthemi NCPPB 1125. The L-asparaginase gene of E. chrysanthemi was cloned and sequenced. The amino acid sequence predicts a 327-residue protein preceded by a signal peptide of 21 residues.

Wang, J.Jie.; Zhang, X.; Zhang, B.Qin.; Wang, G.; Yu, X.Qiang., 2008: 9-Ethyl-3,6-diformyl-9H-carbazole. The structure of the title compound, C(16)H(13)NO(2), was determined as a part of a project on the synthesis of new compounds which can make two-photon absorptions. In the crystal structure, both aldehyde groups are located within the carbazole pl...

Woolf, C.J., 2015: What to call the amplification of nociceptive signals in the central nervous system that contribute to widespread pain?. Pain 155(10): 1911-1912

Lin, B-Ren.; Chang, C-Chi.; Chen, R.Jeen-Chen.; Jeng, Y-Ming.; Liang, J-Tung.; Lee, P-Huang.; Chang, K-Jen.; Kuo, M-Liang., 2011: Connective tissue growth factor acts as a therapeutic agent and predictor for peritoneal carcinomatosis of colorectal cancer. Clinical Cancer Research 17(10): 3077-3088

Yoshioka, M.; Grenier, D.; Hinode, D.; Fukui, M.; Mayrand, D., 2004: Antigenic cross-reactivity and sequence homology between Actinobacillus actinomycetemcomitans GroEL protein and human fibronectin. The immunological cross-reactivity between human fibronectin and Actinobacillus [Haemophilus] actinomycetemcomitans GroEL was examined. Analyses by SDS-PAGE/Western immunoblotting and ELISA showed that a polyclonal antibody directed against the pu...

Fornara, P.; Zacharias, M., 2004: Minimal invasiveness of laparoscopic radical prostatectomy: reality or dream?. Currently, radical retropubic prostatectomy is the standard procedure for clinically localized prostate cancer. The surgical technique has been continuously refined for decades, resulting in reduced morbidity and improved functional and oncologic...

T. C. Johnson; P. S. Routh; T. Clemo; W. Barrash; W. P. Clement, 2007: Incorporating geostatistical constraints in nonlinear inversion problems. Water Resources Research 43(10)

Wolfe, David W.; Farquhar, C. Craig; Nguyen, Phi A.; Maresh, John, 1997: Habitat management for the federally endangered Black-capped Vireo at the Camp Barkeley National Guard Training Site. Bulletin of the Ecological Society of America 78(4 SUPPL ): 332

Reamer, F.G., 2007: Documentation in social work: evolving ethical and risk-management standards. Social workers' understanding of the relevance of documentation has evolved over time. During the profession's earliest years, social workers viewed documentation primarily as a mechanism to facilitate theory building, research, and teac...