EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
EurekaMag PDF Full Text Supply ServicePDF Full Text Supply Service
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn
Follow on LinkedInFollow on Tumblr

+ Translate

Regulation of influenza virus-specific cytotoxic T cell responses by monoclonal antibody to a human T cell differentiation antigen


, : Regulation of influenza virus-specific cytotoxic T cell responses by monoclonal antibody to a human T cell differentiation antigen. Journal of Immunology 127(6): 2236-2240

The results in this report indicate that the OKT3 monoclonal antibody, which is specific for a human T cell differentiation antigen present on 90 to 95% of peripheral T cells, can exert several effects that regulate the generation and expression of human influenza virus-immune cytotoxic T lymphocytes (CTL). The OKT3 antibody, but not OKT1 or OKT11 (which bind to all peripheral T cells), is able to inhibit anti-influenza CTL effector cell activity. An F(ab')2 preparation of OKT3 IgG were as effective as whole IgG for the inhibition of CTL effectors, indicating that the inhibitory activity of the antibody was not a function of the Fc portion of the molecule. OKT3 IgG and OKT3 F(ab')2 fragments (but not OKT4, OKT8, or OKI were able to inhibit the generation of anti-influenza CTL. The culture of human lymphoid cells with OKT3 in the presence or absence of influenza virus induced radioresistant cells that could suppress the CTL response of fresh autologous lymphocytes to influenza. These results suggest that T cell functions can be regulated by signals that are initiated by the binding of antibody to cell surface molecules that may not be related to the T cell antigen-specific receptor(s).

(PDF 0-2 workdays service)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 044174578

PMID: 6457869

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Fox, S.; Khoury, A.; Mootabar, H.; Greenwald, E.F., 1987: Myositis ossificans progressiva and pregnancy. Myositis ossificans progressiva is a rare inherited ossifying condition of the striated muscle tissue. In the English language literature there is no reported association of this disease with an advanced state of pregnancy, nor is there any well-d...

Nieuwenhuijse, J. A., 1993: Heat stability of concentrated skim milk. The mechanisms of coagulation of conc. milk were studied. The work involved determining changes in Ca ion activity, pH, and partition of Ca2+ and phosphate between serum and particles, induced by concentrating whole milk and by heating conc. milk....

Lu, M. X.; Mao, L. C.; Zhao, D. S., 1993: Physiological effects of preservative for prolonging the longevity of cut carnation flowers. Cut carnation flowers were held either in water (control) or in a preservative solution that contained 5% sucrose, 200 p.p.m. 8-hydroxyquinoline and 100 p.p.m. silver acetate. The peaks of ethylene release and respiration climacteric were delayed...

Pietras, T.; Nowak, D.; Marczak, J.; Mazerant, P.; Leder, M.; Romanowska, M.; Kurmanowska, Z.; Rozalski, A.; Radziejewska Lebrecht, J.; Antczak, A., 1996: Lipid peroxidation in murine lungs after injection of different variant of lipopolysaccharide from proteus mirabilis. European Respiratory Journal Supplement 9(23): 186S

Murai M.; Morimoto H.; Maeda Y.; Fujii T., 1992: Effects of the tripeptide substance p antagonist fr113680 on airway constriction and airway edema induced by neurokinins in guinea pigs. FR113680 is a newly developed tripeptide substance P (SP) receptor antagonist. The effects of FR113680 on airway constriction and airway edema induced by neurokinins were investigated in guinea-pigs. In in vitro experiments, FR113680 inhibited the...

Collins, G.F.; Cassie, J.M.; Daggett, C.J., 1978: The role of the attending physician in clinical training. Journal of Medical Education 53(5): 429-431

Capdevila Raymond, 1962: Etude petrographique et structurale du complexe volcanique de Saint-Thibery (Herault). The middle Pleistocene volcanic complex between Bessan and Saint Thibery (France) is composed of basanite volcanic material. Three main formations are recognized: tuffs, cones, and flows. Petrographic analysis of the material shows that the basani...

Missliwetz, J.; Benzer, H.; Coraim, F.; Friedrich-Schöler, E.; Passl, R., 1978: Changes of lungs during traumatic shock--a morphological study on early fixated organ. Verhandlungen der Deutschen Gesellschaft für Pathologie 62(): 213-218

Wang, P., 2002: Report on fourth epidemiological survey for tuberculosis in Heilongjiang province. Objective: To investigate the epidemiological trend of tuberculosis, to evaluate the efficacy of control measures and to provide scientific evidence for provincial 2001apprx2010 tuberculosis control programme. Methods: Tuberculin testing was carri...

Sadasivam, K. V.; Mathur, R. S.; Magu, S. P.; Gaur, A. C., 1981: Enrichment of compost by Azotobacter and phosphate solubiliser. Inoculating rock-phosphate-amended composts with cultures of Azotobacter chroococcum and the phosphate dissolving strain Aspergillus awamorii increased their total nitrogen and humus contents.