+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
EurekaMag PDF Full Text Supply ServicePDF Full Text Supply Service
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn
Follow on LinkedInFollow on Tumblr

+ Translate

Regulation of interleukin 2 receptor expression on murine cytotoxic T lymphocyte clones

, : Regulation of interleukin 2 receptor expression on murine cytotoxic T lymphocyte clones. Journal of Immunology 132(2): 839-844

We have previously reported that influenza virus-specific cytotoxic T lymphocyte (CTL) clones require antigen and exogenous growth factors for continued proliferation in culture. In this report we show that after stimulation with specific antigen, cloned CTL are capable of limited proliferation in response to interleukin 2 (IL 2) alone but with time these large blast-like cells revert to smaller, quiescent cells that are no longer responsive to IL 2. The IL 2-unresponsive CTL can not be driven to proliferate by supra-optimal concentrations of IL 2, and unresponsiveness correlates with decreased ability to absorb IL 2 from conditioned medium at 0 degrees C, suggesting that unresponsiveness is due to diminished IL 2 receptors. Stimulation of the unresponsive CTL with antigen leads to re-expression of the IL 2 receptor. Decreased absorbing capacity of the unresponsive cells could not be accounted for by their smaller surface area, and the IL 2-unresponsive cells seemed not to down-regulate all their immune functions, as they remained cytotoxic. These results provide a basis for the role of specific antigen in maintaining CTL clones in vitro. Furthermore, these results suggest that antigen-dependent CTL lines can be regulated and that antigen and IL 2 both play a role in their regulation.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 044174613

PMID: 6418812

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Borselli, L.; Pellegrini, S.; Torri, D.; Bazzoffi, P., 2002: Tillage erosion and land levelling: evidences in Tuscany (Italy). Mechanical operations are responsible for the translocation of large quantities of soil. Both usual tillage practices (deep ploughing and discing) and land levelling cause great modifications to the landscape in hilly agricultural areas; the main...

Farmer, L. J., 1965: The phloem-yeast complex during infestations of the mountain Pine beetle in Lodgepole Pine. Two infestations studied, one old and one new, had similar barkbeetle/yeast associations. Four yeast species were common to both, with a fifth species differing. Some properties of yeast-infected phloem were analysed. It is suggested that, as well...

Bastarrachea F.; Osorio A., 1980: Mutations in the gene glna of escherichia coli produced by insertion of the bacterio phage mu. Revista Latinoamericana de Microbiologia 22(1): 30

Pagano, E.; Monaldi, V., 1990: The address of the President of U.S.L. 41 on the inaugural celebration of the Monaldi Year. Archivio Monaldi Per le Malattie del Torace 45(2): 85-94

Halbert E. J. M., 1984: Prediction of climatic temperature data for karst areas in the Central and Southern Tablelands of New South Wales. Helictite 21(2): 55-63

Lenkeit, W., 1931: Significance of the forestomach in animals with onechambered stomachs for the utilization of carbohydrates (experiments with white rats). As in the horse the stomach of the rat consists of an anterior portion lined with stratified epithelium and a distal or glandular portion. Normal rats killed 1-2 hours after a meal of starch had changed 8-10 per cent, into sugar in the fore-stomac...

Torugsa, Kalyanee, 1994: Prevalence of HIV-1 infection in young men entering the Royal Thai Army; Trends and risk factors. TENTH INTERNATIONAL CONFERENCE ON AIDS, INTERNATIONAL CONFERENCE ON STD [Author] Tenth International Conference on AIDS and the International Conference on STD, Vol 1; The global challenge of AIDS: Together for the future : 1) 284

Sims John D., 1988: Late Quaternary climate, tectonism, and sedimentation in Clear Lake, Northern California Coast Ranges. Special Paper - Geological Society of America 214: 1-8

Ratner, E. S., 1955: Relation of the visual characteristics to fluctuating quanta of light. Working from the material of new literature and particularly from experimental data (Blackwell, H. R., J. Opt. Soc. America 36(11): 624. 1946.) concerning the dependence of the resolving power of the human eye on the brightness and contrast of the...

Alvares, A.P.; Kappas, A.; Levin, W.; Conney, A.H., 1973: Inducibility of benzo( )pyrene hydroxylase in human skin by polycylic hydrocarbons. Clinical Pharmacology and Therapeutics 14(1): 30-40