EurekaMag.com logo
+ Site Statistics
References:
47,893,527
Abstracts:
28,296,643
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Relationship between ornithine decarboxylase-inducing activity and configuration at C-4 in phorbol ester derivatives


, : Relationship between ornithine decarboxylase-inducing activity and configuration at C-4 in phorbol ester derivatives. Journal of Cancer Research and Clinical Oncology 98(1): 9-13

Measurements were made of induction of ornithine decarboxylase activity after painting mouse skin with 12-O-hexadecanoyl-16-hydroxyphorbol-13-acetate and its two epimeric 4-deoxy-analogs, 12-O-hexadecanoyl-4-deoxy-16-hydroxyphorbol-13-acetate and 12-O-hexadecanoyl-4-deoxy-4 alpha-16-hydroxyphorbol-13 acetate. The inductive activities of HHPA and 4-deoxy-HHPA were similar, but 4-deoxy-4 alpha HHPA had no inductive activity. These findings on natural phorbol esters confirm that both the 4 beta-hydrogen and the 4 beta-hydroxyl in phorbol esters are essential for ODC-inducing activity. The interactions of 4-deoxy-HHPA and 4-deoxy-4 alpha-HHPA with a possible receptor are discussed.


Accession: 044184985

PMID: 7451556

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Fujiki H.; Mori M.; Sugimura T.; Hirota M.; Ohigashi H.; Koshimizu K., 1980: Relationship between ornithine decarboxylase inducing activity and configuration at carbon 4 in phorbol ester derivatives. Measurements were made of induction of ornithine decarboxylase activity after painting mouse skin with [the tumor promoter], 12-O-hexadecanoyl-16-hydroxyphorbol-13-acetate [HHPA] and its 2 epimeric 4-deoxy-analogs, 12-O-hexadecanoyl-4-deoxy-16-hyd...

Byus, C.V.; Weiner, R.A., 1982: Tumor promoting phorbol-ester derivatives increase ornithine decarboxylase activity and polyamine biosynthesis in the liver of the rat and mouse. The ability of the phorbol-ester tumor promoters to alter ornithine decarboxylase (ODC) activity in the liver of the rat and mouse was determined. The injection of 12-O-tetra-decanoyl phorbol-13-acetate (TPA, 100 microgram, i.p.) led to a 250-fold...

Byus, C.V.; Weiner, R.A., 1982: Tumor promoting phorbol ester derivatives increase ornithine decarboxylase ec 4.1.1.17 activity and poly amine biosynthesis in the liver of the rat and mouse. The ability of the phorbol-ester tumor promoters to alter ornithine decarboxylase (ODC) activity in the liver of the rat and mouse was determined. The injection of 12-O-tetradecanoyl phorbol-13-acetate (TPA, 100 .mu.g, i.p.) led to a 250-fold incr...

Luyengi, L.; Lee, I.S.o; Mar, W.; Fong, H.H.S.; Pezzuto, J.M.; Kinghorn, A.D.uglas, 1994: Rotenoids and chalcones from Mundulea sericea that inhibit phorbol ester-induced ornithine decarboxylase activity. Two novel rotenoids, (-)-13-alpha-hydroxydeguelin and (-)-13-alpha-hydroxytephrosin, and a new chalcone, munsericin, were isolated from the bark of Mundulea sericea, and their structures were elucidated by spectroscopic methods. Also obtained were...

Lockyer, J.M.; Magun, B.E., 1983: The effects of serum and phorbol ester tumor promoter on ornithine decarboxylase activity in Swiss 3T3 cells. Addition of the tumor promotor 12-O-tetradecanoyl phorbol-13-acetate (TPA) to serum-deprived mouse 3T3 cells resulted in an increase in ornithine decarboxylase activity which is maximal at 3 h and declined thereafter. Addition of serum to these sa...

Hibasami, H.; Tsukada, T.; Maekawa, S.; Sakurai, M.; Nakashima, K., 1987: Induction of ornithine decarboxylase activity in mouse tissues by phorbol ester is effectively blocked by methylglyoxal bis(butylamidinohydrazone). Ornithine decarboxylase (ODC) was induced in the liver, lung and brain of the mouse injected intraperitoneally with 12-O-tetradecanoylphorbol 13-acetate (TPA), showing maximal enzyme activity four hours after the injection. The increase of ODC act...

Loprinzi, C.L.; Verma, A.K., 1984: Effects of local anesthetics on phorbol ester-induced ornithine decarboxylase activity in mouse and human skin. In preparation for experiments to determine the effects of various orally administered compounds on human skin ornithine decarboxylase (ODC) activity, it was observed that intradermal lidocaine hydrochloride inhibited 12-0-tetradecanoylphorbol-13-...

Xue, G.Z.en; Zheng, Z.S.eng; Chen, R.Z.en; Prystowsky, J.H., 1994: Effects of phorbol ester on 125I-EGF binding and ornithine decarboxylase activity in SV40 transformed human keratinocytes. Journal of Investigative Dermatology 102(4): 627

Smith, M.A.L.; Bomser, J.; Singletary, K.; Seigler, D., 1998: Inhibition of phorbol ester -induced mouse epidermal ornithine decarboxylase activity by Vaccinium macrocarpon AIT extracts. FASEB Journal 12(5): A831, March 20

Muhtasib H.U.; Perchellet E.M.; Perchellet J.P., 1991: Tannic acid inhibition of phorbol ester induced ornithine decarboxylase activity in mouse epidermis in vivo. Proceedings of the American Association for Cancer Research Annual Meeting 32: 151