EurekaMag.com logo
+ Site Statistics
References:
54,215,046
Abstracts:
30,230,908
PMIDs:
28,215,208
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Relationship between the levels of cyclic cytidine 3':5'-monophosphate, cyclic guanosine 3':5'-monophosphate, and cyclic adenosine 3':5'-monophosphate in urines and leukocytes and the type of human leukemias



Relationship between the levels of cyclic cytidine 3':5'-monophosphate, cyclic guanosine 3':5'-monophosphate, and cyclic adenosine 3':5'-monophosphate in urines and leukocytes and the type of human leukemias



Cancer Research 41(8): 3222-3227



Cyclic cytidine 3':5'-monophosphate (cyclic CMP), cyclic guanosine 3':5'-monophosphate (cyclic GMP), and cyclic adenosine 3':5'-monophosphate (cyclic AMP) contents of leukocytes and urines of leukemic patients have been investigated. We have studied four types of leukemia: acute myeloblastic leukemia; chronic myelocytic leukemia; acute lymphoblastic leukemia; and chronic lymphocytic leukemia. As controls, the cyclic nucleotide content of leukocytes and urines of healthy volunteers and patients with solid tumors selected for their normal hemogram has been determined. It has also been measured in phytohemagglutinin-stimulated lymphocytes. Our data show that: (a) the concentration of cyclic CMP is always lower than that of cyclic GMP or cyclic AMP; (b) in urines, the concentrations of the three nucleotides are higher in patients than in healthy volunteers, the greatest differences being observed between the cyclic CMP concentrations of acute leukemia patients and controls; and (c) in white blood cells, cyclic AMP concentration is lower in leukemic than in normal cells. The cyclic GMP concentration is the same everywhere except in monoblastic cells and leukocytes from solid tumor patients. High cyclic CMP levels are associated only with acute leukemia, whether myeloblastic, monoblastic, or lymphoblastic, a fact which suggests that cyclic CMP could be a biochemical marker of hematopoietic stem cell malignancy.

(PDF emailed within 1 workday: $29.90)

Accession: 044186043

Download citation: RISBibTeXText

PMID: 6265079



Related references

Levels of cyclic adenosine-3',5'-monophosphate (cyclic AMP) and cyclic guanosine-3',5'-monophosphate (cyclic GMP) in human lumbar and ventricular cerebrospinal fluid. Changes in coma. Acta Neurologica. Quaderni 37: 9-17, 1978

Self-phosphorylation of cyclic guanosine 3':5'-monophosphate-dependent protein kinase from bovine lung. Effect of cyclic adenosine 3':5'-monophosphate, cyclic guanosine 3':5'-monophosphate and histone. Journal of Biological Chemistry 252(8): 2780-2783, 1977

Measurements of cyclic adenosine monophosphate and cyclic guanosine monophosphate levels in polymorphonuclear leukocytes, macrophages, and lymphocytes. Methods in Enzymology 132: 428-434, 1986

Alpha adrenergic involvement in heart metabolism: effects on adenosine cyclic 3',5'-monophosphate, adenosine cyclic 3',5'-monophosphate-dependent protein kinase, guanosine cyclic 3',5'-monophosphate, and glucose transport. Molecular Pharmacology 13(5): 965-975, 1977

An equilibrium study of the cooperative binding of adenosine cyclic 3',5'-monophosphate and guanosine cyclic 3',5'-monophosphate to the adenosine cyclic 3',5'-monophosphate receptor protein from Escherichia coli. Biochemistry 19(22): 5124-5130, 1980

Circadian rhythms in the urinary excretion of cyclic 3',5'-adenosine monophosphate (cyclic AMP) and cyclic 3',5'-guanosine monophosphate (cyclic GMP) in human subjects. Journal of Clinical Endocrinology and Metabolism 44(4): 673-680, 1977

Adenosine 3',5'-cyclic monophosphate and guanosine 3',5'-cyclic monophosphate levels in human breast cancer tissue. Oncology 34(6): 261-263, 1977

Double antibody enzyme immunoassay for the quantitation of adenosine 3', 5' -cyclic monophosphate (cyclic AMP) and guanosine 3', 5'-cyclic monophosphate (cyclic GMP) in tissue and plasma. Journal of Immunoassay 3(2): 173-196, 1982

Double Antibody Enzyme Immunoassay for the Quantitation of Adenosine 3,5-Cyclic Monophosphate (Cyclic AMP) and Guanosine 3,5-Cyclic Monophosphate (Cyclic GMP) in Tissue and Plasma. Journal of Immunoassay 3(2): 173-196, 1982

Relationship of adenosine 3',5'-cyclic monophosphate and guanosine 3',5'-cyclic monophosphate to growth of dimethylbenz(a)anthracene-induced mammary tumors in rats. Journal of the National Cancer Institute 56(3): 659-661, 1976

Regulation of adenosine cyclic 3',5'-monophosphate and guanosine cyclic 3',5'-monophosphate levels and contractility in bovine tracheal smooth muscle. Molecular Pharmacology 13(2): 330-341, 1977

Comparison of cyclic adenosine 3':5'-monophosphate and cyclic guanosine 3':5'-monophosphate levels, cyclases, and phosphodiesterases in Morris hepatomas and liver. Cancer Research 37(10): 3599-3606, 1977

Sodium nitroprusside and neurostimulation cause increased levels of cyclic guanosine monophosphate and not cyclic adenosine monophosphate during canine penile erection. Biochemistry and Molecular Biology International 29(1): 167-173, 1993

Effect of ascorbic acid on plasma adenosine 3',5'-cyclic monophosphate and guanosine 3',5'-cyclic monophosphate levels in the baboon, Papio ursinus. South African Journal of Science 71(1): 28-29, 1975

Plasma levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) in patients with thyropathies. Casopis Lekaru Ceskych 123(27): 835-837, 1984