+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Renal thrombotic microangiopathy in a patient with rheumatoid arthritis and antiphospholipid syndrome: successful treatment with cyclophosphamide pulse therapy and anticoagulant



Renal thrombotic microangiopathy in a patient with rheumatoid arthritis and antiphospholipid syndrome: successful treatment with cyclophosphamide pulse therapy and anticoagulant



Internal Medicine 33(8): 484-487



A female patient with a history of migraines and chorea developed polyarthralgia at age 24 and was diagnosed with rheumatoid arthritis. In 1991 she was hospitalized because of impaired renal function and hypertension. Examination revealed thrombocytopenia and the presence of lupus anticoagulant. Antinuclear antibody was weakly positive, but anti-DNA antibody was negative, and no decrease in leukocyte count or complement level was observed. Rheumatoid arthritis with antiphospholipid syndrome was diagnosed. Renal biopsy showed renal thrombotic microangiopathy. This renal lesion was considered to be associated with antiphospholipid syndrome. Cyclophosphamide pulse therapy and anticoagulation therapy decreased proteinuria and improved renal function.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 044198686

Download citation: RISBibTeXText

PMID: 7803916

DOI: 10.2169/internalmedicine.33.484


Related references

Renal thrombotic microangiopathy and antiphospholipid syndrome nephropathy in a patient with lupus nephritis. Nihon Jinzo Gakkai Shi 58(1): 45-54, 2016

Primary antiphospholipid syndrome presenting as thrombotic microangiopathy: Successful treatment with steroids, plasma exchange and anticoagulants. Indian Journal of Nephrology 21(4): 280-282, 2011

A 3-year follow-up of a patient with acute renal failure caused by thrombotic microangiopathy related to antiphospholipid syndrome: case report. Lupus 26(7): 777-782, 2017

Antiphospholipid syndrome and renal thrombotic microangiopathy. JN Journal of Nephrology 8(3): 123-125, 1995

Combined treatment with cyclophosphamide and prednisolone can induce remission of nephrotic syndrome in a patient with renal amyloidosis, associated with rheumatoid arthritis. Clinical Nephrology 42(1): 30-32, 1994

Reversible renal failure due to the antiphospholipid antibody syndrome, pre-eclampsia and renal thrombotic microangiopathy. Clinical Nephrology 44(4): 271-273, 1995

Thrombotic microangiopathy: An unusual cause of renal failure in rheumatoid arthritis. Indian Journal of Nephrology 27(1): 81-83, 2017

Primary antiphospholipid syndrome paps associated with renal thrombotic microangiopathy tma report of 4 cases. Journal of the American Society of Nephrology 2(3): 267, 1991

Renal thrombotic microangiopathy in patients with systemic lupus erythematosus and the antiphospholipid syndrome. American Journal of Kidney Diseases 20(2): 150-158, 1992

Thrombotic microangiopathy and poor renal outcome in lupus patients with or without antiphospholipid syndrome. Clinical and Experimental Rheumatology 33(4): 503-508, 2015

De novo thrombotic microangiopathy in renal transplant recipients: a comparison of hemolytic uremic syndrome with localized renal thrombotic microangiopathy. American Journal of Kidney Diseases 41(2): 471-479, 2003

Catastrophic antiphospholipid syndrome presenting with renal thrombotic microangiopathy and diffuse proliferative glomerulonephritis. Clinical and Experimental Rheumatology 24(1): 110, 2006

Catastrophic Antiphospholipid Syndrome Presenting as Congestive Heart Failure in a Patient with Thrombotic Microangiopathy. Texas Heart Institute Journal 46(1): 48-52, 2019

Successful treatment of a patient with severe Churg-Strauss syndrome by a combination of pulse corticosteroids, pulse cyclophosphamide, and high-dose intravenous immunoglobulin. Journal of Asthma 42(8): 639-641, 2005

A case of primary antiphospholipid antibody syndrome with acute renal failure showing thrombotic microangiopathy. American Journal of Nephrology 19(5): 594-598, 1999