Role of histamine in regulation of blood flow in the injured gastric mucosa of the cat

Gislason, H.; Svanes, K.

Journal of Physiology and Pharmacology An Official Journal of the Polish Physiological Society 45(3): 369-376


ISSN/ISBN: 0867-5910
PMID: 7841450
Accession: 044251997

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Superficial mucosal damage caused by a mild irritant (2 M NaCl) results in release of histamine and probably prostaglandins giving increased GMBF. This hyperemic response contributes to protect the mucosa during the early phase of repair after damage by supplying the mucosa with bicarbonate and by eliminating back diffusing acid and other toxic substances such as ethanol. We conclude that histamine plays an important role in the blood flow regulation in the stomach.