+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

S-adenosyl methionine-mediated repression of methionine biosynthetic enzymes in Saccharomyces cerevisiae



S-adenosyl methionine-mediated repression of methionine biosynthetic enzymes in Saccharomyces cerevisiae



Journal of Bacteriology 114(3): 928-933



S-adenosylmethionine (SAM) has been shown to provoke repression of some methionine-specific enzymes in wild-type cells, namely, adenosine triphosphate sulfurylase, sulfite reductase, and homocysteine synthetase. Repressive effects observed in SAM-supplemented cultures should be due to SAM per se, since the intracellular pool of SAM increases while the intracellular pool of methionine remains low and constant. Derepression brought about by methionine limitation is accompanied by a severe decrease in SAM as well as methionine pool sizes, although methionine adenosyl transferase is slightly derepressed. Different hypotheses have been considered to account for the previously reported implication of methionyl transfer ribonucleic acid and the presently reported SAM effects in this regulatory process.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 044263642

Download citation: RISBibTeXText

PMID: 4576408


Related references

Methionine-and S-adenosyl methionine-mediated repression in a methionyl-transfer ribonucleic-acid synthetase mutant of Saccharomyces cerevisiae. Journal of Bacteriology 123(2): 428-435, 1975

S-adenosyl methionine requiring mutants in Saccharomyces cerevisiae: evidences for the existence of two methionine adenosyl transferases. Molecular and General Genetics 163(2): 153-167, 1978

S adenosyl methionine requiring mutants in saccharomyces cerevisiae evidences for the existence of 2 methionine adenosyl transferases. Molecular and General Genetics 163(2): 153-168, 1978

Inhibition of rna synthesis by s adenosyl methionine during glucose de repression in saccharomyces cerevisiae. Abstracts of the Annual Meeting of the American Society for Microbiology 77: 367, 1977

Evidence that s adenosyl methionine functions as an extracellular regulatory signal during glucose de repression in saccharomyces cerevisiae. Federation Proceedings: 1418, 1978

Induction and repression in the S-adenosylmethionine and methionine biosynthetic systems of Saccharomyces cerevisiae. Journal of Bacteriology 116(2): 812-817, 1973

Enhanced S-adenosyl-l-methionine production in Saccharomyces cerevisiae by spaceflight culture, overexpressing methionine adenosyltransferase and optimizing cultivation. Journal of Applied Microbiology 112(4): 683-694, 2012

The two methionine adenosyl transferases in Saccharomyces cerevisiae: evidence for the existence of dimeric enzymes. Molecular and General Genetics 182(1): 65-69, 1981

The 2 methionine adenosyl transferases in saccharomyces cerevisiae evidence for the existence of dimeric enzymes. Molecular & General Genetics 182(1): 65-69, 1981

SAM2 encodes the second methionine S-adenosyl transferase in Saccharomyces cerevisiae: physiology and regulation of both enzymes. Molecular and Cellular Biology 8(12): 5132-5139, 1988

Regulatory mutations concerning threonine and methionine biosynthetic enzymes in Saccharomyces cerevisiae. Genetics today. Proceedings of the XI International Congress of Genetics, The Hague, The Netherlands, September, 1963. 1: 35-36, 1963

Kinetic properties of s adenosyl methionine delta 24 sterol methyl transferase enzymes ec 2.1.1.41 in mitochondrial structures of saccharomyces cerevisiae. Biochimica et Biophysica Acta 334(1): 127-136, 1974

S-adenosyl methionine requiring mutants inSaccharomyces cerevisiae:Evidences for the existence of two methionine adenosyl transferases. Molecular Genetics and Genomics 163(2): 153-167, 1978

Uptake and utilization of S-adenosyl-L-methionine and S-adenosyl-L-homocysteine in an adenine mutant of Saccharomyces cerevisiae. Journal of Bacteriology 98(2): 629-636, 1969

Lack of influence of s adenosyl l methionine s adenosyl l methionine treatment on walker 256 b carcinoma and s adenosyl l methionine turnover in rats. Toxicology Letters 12(2-3): 207-214, 1982