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Selectin receptors. 2. Synthesis of HSO3-3'Le(a)--a sulfated ligand of the cell adhesion molecule, E-selectin



Selectin receptors. 2. Synthesis of HSO3-3'Le(a)--a sulfated ligand of the cell adhesion molecule, E-selectin



Bioorganicheskaia Khimiia 20(5): 556-559



HSO3-3'Gal beta 1-3(Fuc alpha 1-4)GlcNAc beta 1-O(CH2)3NH2 was synthesized by selective sulfation (Py.SO3/Py, O degree C) of a protected trisaccharide Lea derivative bearing unsubstituted hydroxyls at C2 and C3 of the galactose moiety, BdGal beta 1-3(Bn3Fuc alpha 1-4)6-BnGlcNAc beta 1-O(CH2)3NHCOCF3, followed by convenient deprotection. A monosaccharide derivative, HSO3-3Gal beta 1-O(CH2)3NH2, was also obtained in a similar way. Coupling of the aminopropyl glycosides with poly(4-nitrophenylacrylate) gave rise to polyacrylamide (PAA) conjugates; biotinylated probes of the Sug-PAA-biotin type were obtained as well.

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Accession: 044284730

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PMID: 7519858


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