+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Serologic and biochemical analyses of a variant Ae (E beta) ia polypeptide chain in D2.gD (H-2g2)



Serologic and biochemical analyses of a variant Ae (E beta) ia polypeptide chain in D2.gD (H-2g2)



Journal of Immunology 127(2): 811-813



Recombinant D2.Gd (KdAdBbJbEbCbSbDb) was derived from parental strains B6 (H-2b) and DBA/2 H-2d). Recent peptide studies and 2-D electrophoresis studies from other laboratories have shown that the Aed (E beta) chain of D2.GD is structurally different from the parental-derived chain. An antiserum (D2.GD X A. TFR5)F1 anti-DBA/2 was produced that detects an Ia specificity (Ia.50) in the I-E molecule formed by the parent Aed chain and lacking in the I-E molecule formed by the variant Aed. chain. The variant Ae chain could have derived either from a mutational event or an intracistronic cross-over.

(PDF emailed within 1 workday: $29.90)

Accession: 044301236

Download citation: RISBibTeXText

PMID: 6166686


Related references

Biochemical characterization of the beta-chain variant haptoglobin Marburg. Humangenetik 7(4): 337-343, 1969

Structure and properties of hemoglobin C-Harlem, a human hemoglobin variant with amino acid substitutions in 2 residues of the beta-polypeptide chain. Journal of Biological Chemistry 242(2): 248-255, 1967

Hemoglobin C Ziguinchor alphaA2 beta62 (A3) Glu leads to Val beta58 (E2) Pro leads to Arg: the second sickling variant with amino acid substitutions in 2 residues of the beta polypeptide chain. Febs Letters 58(1): 149-154, 1975

The contribution of beta-strand residues to serologic epitopes on the A beta k polypeptide. Immunogenetics 33(5-6): 409-412, 1991

Amino acid sequence in all the tryptic peptides from the beta polypeptide chain of adult hemoglobin of the Rhesus monkey (Macaca mulatta). Biochemical studies on hemoglobins and myoglobins. III. International Journal of Protein Research 2(2): 83-97, 1970

Hemoglobin Cranston, an unstable variant having an elongated beta chain due to nonhomologous crossover between two normal beta chain genes. Proceedings of the National Academy of Sciences of the United States of America 72(9): 3609-3613, 1975

Translation in xenopus laevis oocytes of hybrid selected lew rat rt1.b a chain and beta chain transcripts results in serologically discrete class ii polypeptide chain complexes. Molecular Immunology 26(2): 171-180, 1989

JMH variants: Serologic, clinical, and biochemical analyses in two cases. Transfusion 35(11): 925-930, 1995

Hybrid Ia antigens: genetic, serologic, and biochemical analyses. Journal of Supramolecular Structure 14(1): 97-106, 1980

Serologic and biochemical studies of a previously unclassified blood type B variant. Blood 63(3): 711-713, 1984

Linkage analyses using biochemical variants in mice. I. Linkage of the hemoglobin beta-chain and glucosephosphate isomerase loci. Biochemical Genetics 3(5): 507-515, 1969

Serologic and biochemical analyses of rat class II molecules with anti-Ia sera. Transplantation Proceedings 13(2): 1364-1366, 1981

Molecular variant of the beta chain of spectrin associated with hereditary elliptocytosis the le puy variant. Nouvelle Revue Francaise d'Hematologie 24(4): 271, 1982

Interaction of the beta chain variant hemo globin leslie and the alpha chain variant hemo globin montgomery in a black female. American Journal of Hematology 8(2): 139-148, 1980

Compound heterozygosity for two beta chain variants: Hb S [beta 6(A3)Glu-->Val] and the high affinity variant Hb San Diego [beta 109(G11)Val-->Met. Hemoglobin 19(1-2): 27-32, 1995