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Specificity patterns of different types of human fucosidase. Recognition of a certain region of the pyranose ring in sugars by the enzymes

, : Specificity patterns of different types of human fucosidase. Recognition of a certain region of the pyranose ring in sugars by the enzymes. Biochimica et Biophysica Acta 659(2): 434-444

Data on the hydrolysis of fucosides, galactosides and arabinosides by different types of fucosidase are presented. The comparative study of the splitting of alpha-L-fucoside and beta-D-arabinoside with a similar structure at C1--C4 of the pyranose ring and the preparation of the enzyme by affinity chromatography showed that both substrates were hydrolysed by the same enzyme, alpha-L-fucoside(beta-D-arabinoside)hydrolase. The analogous investigation of the hydrolysis of beta-D-fucoside, beta-D-galactoside and alpha-L-arabinoside with a similar structure at C1--C4 of the pyranose ring demonstrated that these glycosides were split by the same enzyne, beta-D-fucoside(beta-D-galactoside, alpha-L-arabinoside)hydrolase, the activity of which is decreased dramatically in GM1-gangliosidosis. The data obtained support the assumption that the specific action of different types of fucosidase is due to recognition by these enzymes of C1--C4 of the pyranose ring in the corresponding substrates. The problems of differential diagnosis of some glycosidoses (focosidosis, GM1-gangliosidosis and Fabry disease) are discussed on the basis of the data obtained.

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Accession: 044374910

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