Studies on the mechanism of action of rabbit anti-mouse thymocyte serum. I. Induction of suppressor cells

Simpson, M.; Gozzo, J.J.

Transplantation 30(1): 64-68


ISSN/ISBN: 0041-1337
PMID: 6967234
DOI: 10.1097/00007890-198007000-00014
Accession: 044440081

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Treatment of B6AF1 (C57BL/6 x A/Jax) mice with either rabbit anti-mouse thymocyte serum (ATS) or with both ATS and sheep red blood cells (SRBCs) resulted in the generation of splenic suppressor cells within 5 days. Suppressor activity was determined by injecting secondary syngeneic recipients with both donor cells and SRBCs. Five days later the SRBCs hemolytic effect of their spleen cells was determined. Suppressor cells were found in either whole spleen or enriched T cell suspensions from mice treated with ATS and SRBCs and in only enriched T cell suspensions from mice treated with ATS alone. These results support the possibility that ATS induces a population of suppressor cells and that these cells may be responsible in part for the immune suppression noted after treatment with ATS.