Successful control of intractable nausea and vomiting requiring combined ondansetron and haloperidol in a patient with advanced cancer

Cole, R.M.; Robinson, F.; Harvey, L.; Trethowan, K.; Murdoch, V.

Journal of Pain and Symptom Management 9(1): 48-50

1994


ISSN/ISBN: 0885-3924
PMID: 7513334
DOI: 10.1016/0885-3924(94)90147-3
Accession: 044465734

Download citation:  
Text
  |  
BibTeX
  |  
RIS

Article/Abstract emailed within 0-6 h
Payments are secure & encrypted
Powered by Stripe
Powered by PayPal

Abstract
Chemically induced nausea and vomiting is a common symptom of advanced cancer effected through stimulation of dopamine (D2) or serotonin (5-HT3) receptors located in the chemoreceptor trigger zone (CTZ). These may be blocked by therapeutic doses of haloperidol and ondansetron, respectively. This case, reporting on a single patient acting as her own control, establishes that combined blockade of these receptors is sometimes required to relieve intractable nausea and vomiting. It also demonstrates the value of clinical review, audit of care, and quality assurance in the palliative care setting.