Successful interferon therapy of renal cell carcinoma with tumor thrombus extending into the inferior vena cava--a case report

Nagano, T.; Maeda, O.; Saiki, S.; Kinouchi, T.; Kuroda, M.; Miki, T.; Usami, M.; Nakamura, M.; Kotake, T.; Kobayashi, T.

Nihon Hinyokika Gakkai Zasshi. Japanese Journal of Urology 84(4): 767-770


ISSN/ISBN: 0021-5287
PMID: 7684102
Accession: 044465945

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It is a fact that there are few effective drugs available except for interferon for that treatment of renal cell carcinoma, and the efficacy rate of interferon is less than 10% even if multiple drug regimens are included. We have experienced a case of renal cell carcinoma in whom interferon therapy was successful in reducing the primary lesion and tumor thrombus extending into the inferior vena cava. A 57-year-old man was admitted to our department with a complaint of macroscopic hematuria. Computed tomography and magnetic resonance imaging revealed a right renal tumor and the tumor thrombus. Because of the past history of his myocardial infarction, a radical operation was considered risky. So we started interferon therapy. Four months after the start of interferon therapy, the primary lesion and the tumor thrombus markedly reduced in their size, and the clinical response was evaluated as partial response by response criteria for urological cancer treatment. Therefore, radical nephrectomy and tumor thrombectomy were performed with extracorporeal circulation. Histopathologically, necrosis and lymphocyte infiltration into the cancer cell focus were seen, and these immunologic reactions were considered at the affection of interferon. In some case, interferon therapy is a useful and safe in the treatment of the primary lesion of renal cell carcinoma, and further investigation must be studied.