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Successful treatment of acute dapsone intoxication using charcoal hemoperfusion

Successful treatment of acute dapsone intoxication using charcoal hemoperfusion

Australian and New Zealand Journal of Medicine 13(5): 509-512

A 22 year old female was admitted to hospital two hours after ingesting 4 g of dapsone. Over the next 15 h she developed progressive hemolysis and methemoglobinemia. Charcoal hemoperfusion and sequential dialysis were performed because of the serious risk of fatality following such a massive dose of dapsone. Charcoal hemoperfusion led to rapid clearing of dapsone from the circulation. This resulted in clinical improvement and controlled the progression of hemolysis and methemoglobinemia.

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Accession: 044466801

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PMID: 6228217

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