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Successful treatment of metastatic extragonadal endodermal sinus (yolk sac) tumor in childhood



Successful treatment of metastatic extragonadal endodermal sinus (yolk sac) tumor in childhood



Cancer 48(11): 2371-2374



Two children with metastatic extragonadal endodermal sinus tumor who had failed VAC chemotherapy were treated with combination chemotherapy consisting of cis-platinum, vinblastine, doxorubicin HCl (Adriamycin) and bleomycin (cis-VAB). There was a complete response in both patients with one child remaining tumor-free 3 1/2 years after metastasis and 2 1/2 years after stopping therapy. The main toxic reactions encountered were associated with the use of cis-platinum, but these were manageable and resolved upon completion of therapy. Cis-VAB appears to be a safe and effective regimen for the treatment of metastatic endodermal sinus tumor. A study of the efficacy of cis-VAB in a larger group of children with endodermal sinus tumor of poor prognosis seems indicated.

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Accession: 044466969

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PMID: 6170420

DOI: 10.1002/1097-0142(19811201)48:11<2371::aid-cncr2820481106>3.0.co;2-#


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