Synthesis and structure-activity relationships of 7 beta-[2- (2-aminothiazol-4-yl) acetamido]-cephalosporin derivatives. III. Synthesis and antibacterial activity of 7 beta-[2-amino-2- (2-aminothiazol-4-yl) acetamido]cephalosporins
Ochiai, M.; Morimoto, A.; Okada, T.; Matsushita, Y.; Yamamoto, H.; Aki, O.; Kida, M.
Journal of Antibiotics 33(9): 1022-1030
1980
ISSN/ISBN: 0021-8820 PMID: 7440409 DOI: 10.7164/antibiotics.33.1022
Accession: 044505056
New derivatives of 7 beta-[2-(2-aminothiazol-4-yl)acetamido]cephalosporins having amino group at the 2-position of the 7-acyl moiety were synthesized in the hope that they would show improved antibacterial activity. Some of these compounds (XXa, XXd, XVb) showed improved activity against Enterobacter cloacae. Replacement of the annular amino group by a methyl group caused loss of activity.
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