Section 45
Chapter 44,506

Synthesis and structure-activity relationships of 7 beta-[2- (2-aminothiazol-4-yl) acetamido]-cephalosporin derivatives. III. Synthesis and antibacterial activity of 7 beta-[2-amino-2- (2-aminothiazol-4-yl) acetamido]cephalosporins

Ochiai, M.; Morimoto, A.; Okada, T.; Matsushita, Y.; Yamamoto, H.; Aki, O.; Kida, M.

Journal of Antibiotics 33(9): 1022-1030


ISSN/ISBN: 0021-8820
PMID: 7440409
DOI: 10.7164/antibiotics.33.1022
Accession: 044505056

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New derivatives of 7 beta-[2-(2-aminothiazol-4-yl)acetamido]cephalosporins having amino group at the 2-position of the 7-acyl moiety were synthesized in the hope that they would show improved antibacterial activity. Some of these compounds (XXa, XXd, XVb) showed improved activity against Enterobacter cloacae. Replacement of the annular amino group by a methyl group caused loss of activity.

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