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T lymphocyte subsets in systemic lupus erythematosus. Correlations with corticosteroid therapy and disease activity



T lymphocyte subsets in systemic lupus erythematosus. Correlations with corticosteroid therapy and disease activity



Arthritis and Rheumatism 26(6): 745-750



The contribution of immune regulation to the etiology of systemic lupus erythematosus (SLE) is poorly understood. Using the monoclonal antibodies OKT4 and OKT8, we quantitated, by flow cytometry, T inducer/helper and T cytotoxic/suppressor cells in patients with SLE. Serologically active patients, who had clinical manifestations such as arthritis or rash and were not receiving prednisone, were characteristically lymphopenic due to a marked reduction in OKT4+ cells. Prednisone therapy produced the same phenomenon. Untreated patients, who were serologically inactive, demonstrated no abnormalities. These studies have thus revealed two presumably independent factors that can produce similar immunoregulatory aberrations.

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Accession: 044513381

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PMID: 6602614


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