+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

T-cell chronic lymphocytic leukemia with morphologic and immunologic characteristics of cytotoxic/suppressor phenotype



T-cell chronic lymphocytic leukemia with morphologic and immunologic characteristics of cytotoxic/suppressor phenotype



Mayo Clinic Proceedings 58(11): 709-720



The human cytotoxic/suppressor T-cell subpopulation has characteristic cytoplasmic granules and unique surface antigens that are recognized by OKT8 monoclonal antibody. Using immunocytochemical techniques, we identified three patients with an indolent T-cell lymphoproliferative disorder having morphologic and immunocytochemical characteristics of a cytotoxic/suppressor T-cell phenotype. Review of the literature revealed 22 similar cases, which were frequently associated with neutropenia and anemia. These cases may represent a distinct clinicopathologic entity with an apparently indolent clinical course that differs from other T-cell lymphoproliferative disorders, which are generally considered to be more aggressive diseases.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 044513593

Download citation: RISBibTeXText

PMID: 6226834


Related references

Immunologic phenotype of lymphocytes in chronic B-cell lymphocytic leukemia. II. Studies of immunologic phenotype of peripheral blood and lymph node lymphocytes in patients with chronic lymphocytic leukemia or leukemic forms of lymphoplasmacytoid lymphoma. Acta Haematologica Polonica 23(1): 29-41, 1992

Peripheral T-cell lymphomas with cytotoxic phenotype in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma. American Journal of Surgical Pathology 38(2): 279-288, 2014

T cell chronic lymphocytic leukemia with suppressor phenotype. Clinical & Experimental Immunology 49(2): 401-409, 1982

T cell chronic lymphocytic leukemia with unusual immunologic phenotype and function. Journal of Cellular Biochemistry Suppl. (9 Part A): 126, 1985

T cell chronic lymphocytic leukemia with lymphocytes of unusual immunologic phenotype and function. Blood 65(1): 127-133, 1985

Clonal expansion of cytotoxic/suppressor T cells in B-cell chronic lymphocytic leukemia. Laboratory Investigation 78(1): 134A, 1998

T cell chronic lymphocytic leukemia with suppressor phenotype t 3 plus t 4 minus t 8 plus report of 2 cases. Sangre 29(4A): 449-456, 1984

Bone marrow histopathologic patterns and immunologic phenotype in b cell chronic lymphocytic leukemia. Blut 57(1): 19-24, 1988

In vitro function of a T-cell chronic lymphocytic leukemia with suppressor cell phenotype. Australian and new Zealand Journal of Medicine 16(3): 389-392, 1986

Immunologic phenotype of lymphocytes in chronic B-cell lymphocytic leukemia. I. B- and T-lymphocytes in chronic lymphocytic leukemia. Acta Haematologica Polonica 23(1): 21-27, 1992

T cell chronic lymphocytic leukemia with only suppressor phenotypic and functional characteristics. Quaglino, D And F G J Hayhoe (Ed ) Serono Symposia Publications From Raven Press, Vol 20 The Cytobiology Of Leukaemias And Lymphomas Xxi+501p Raven Press: New York, N Y , Usa Illus 387-392, 1985

CD200 in High-Grade Lymphoma, Chronic Lymphocytic Leukemia, and Chronic Lymphocytic Leukemia-Phenotype Monoclonal B-Cell Lymphocytosis. American Journal of Clinical Pathology 144(4): 677-679, 2015

A case of T-cell chronic lymphocytic leukemia with both helper and suppressor phenotype, and helper function. Japanese Journal of Clinical Hematology 27(8): 1400-1403, 1986

Small lymphocytic non-Hodgkin's lymphoma of suppressor/cytotoxic T-cell phenotype [CD4(-), CD8(+). Human Pathology 24(11): 1253-1256, 1993