+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

T-cell responses induced by the parenteral injection of antigen-modified syngeneic cells. III. Dissociation of primed cytolytic T-cell and efferent suppressor-T-cell activity following intravenous injection of trinitrophenol-modified syngeneic spleen cells



T-cell responses induced by the parenteral injection of antigen-modified syngeneic cells. III. Dissociation of primed cytolytic T-cell and efferent suppressor-T-cell activity following intravenous injection of trinitrophenol-modified syngeneic spleen cells



Cellular Immunology 86(2): 308-316



The parenteral injection of ligand-coupled syngeneic spleen cells has profound effects on immune responsiveness. In this regard, it was examined whether the primed in vitro trinitrophenol (TNP)-specific cytotoxic T-lymphocyte (CTL) responses observed in splenic T-cell populations from mice injected intravenously (iv) with syngeneic TNP-modified spleen cells (TNP-SC) are related to the efferent-acting suppressor-T-cell (Ts) activity observed in splenocytes from iv primed mice. Treatment of mice with cyclophosphamide, adult thymectomy, or monoclonal anti-I-J antiserum prior to the iv injection of TNP-SC was found to eliminate the ability of splenic Ts from these mice to suppress the passive transfer of delayed-type hypersensitivity (DTH) mediated by trinitrochlorobenzene-immune T cells. In contrast, spleen cells from these pretreated mice showed no impairment in the development of augmented TNP-specific CTL responses upon in vitro restimulation with TNP-SC. Separation of the two activities was also achieved in a kinetic analysis. It is concluded that specific enhancement of CTL responsiveness induced by the iv injection of TNP-SC is related to the expansion of a population prelytic Lyt 2+ CTL effector cells which does not appear to contain efferent-acting Lyt 2+ Ts active in suppressing DTH expression.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 044513753

Download citation: RISBibTeXText

PMID: 6234068

DOI: 10.1016/0008-8749(84)90385-x


Related references

T-cell responses induced by the parenteral injection of antigen-modified syngeneic cells. II. Mechanisms, specificity, and cellular analysis of 2,4,6-trinitrophenol (TNP)-specific cytolytic response priming by intravenous versus subcutaneous injection with TNP-modified syngeneic cells. Cellular Immunology 82(2): 378-393, 1983

T cell responses induced by the parenteral injection of antigen modified syngeneic cells 1. induction characterization and regulation of antigen specific t helper cells involved in delayed type hyper sensitivity responses. Journal of Immunology 131(1): 77-85, 1983

Genetic control of contract hypersensitivity. II. Suppressor cells induced by intravenous injection of DNP-coupled syngeneic spleen cells possessing thy-1 antigen, I-J determinant, Lyt-2+, 3+ antigen, FcR- and DNP-membrane binding receptor on their surfaces. Microbiology and Immunology 25(1): 63-70, 1981

In vivo regulation of the cytolytic T cell response to hapten-altered self: suppressor T cells induced in the regional lymph nodes by exposure to syngeneic spleen cells. European Journal of Immunology 14(7): 629-633, 1984

Suppressor cell networks in mice tolerized with di nitro phenyl modified syngeneic spleen cells. Journal of Supramolecular Structure 8(Suppl. 3): 294, 1979

The regulation of various types of cell mediated immune responses against tri nitro phenyl modified syngeneic cells in vivo by different classes of suppressor cells. Zeitschrift Fuer Immunitaetsforschung: 309, 1978

The cytolytic T lymphocyte response to trinitrophenyl-modified syngeneic cells. II. Evidence for antigen-specific suppressor T cells. Journal of Immunology 123(3): 1210-1214, 1979

Immune suppression in vivo with antigen modified syngeneic cells 5. interacting t cell sub populations in the suppressor pathway. Journal of Immunology 125(4): 1862-1868, 1980

The suppressor T cell induced by syngeneic splenic cell antigen down-regulates hapten-specific cytotoxic T cells by elaborating a factor inhibitory for IL2-dependent cell replication. Cellular Immunology 105(1): 220-234, 1987

Suppressor T cell circuits in contact sensitivity. I. Two mechanistically distinct waves of suppressor T cells occur in mice tolerized with syngeneic DNP-modified lymphoid cells. Journal of Immunology 129(2): 461-468, 1982

Epidermal cell-induced generation of cytotoxic T-lymphocyte responses against alloantigens or TNP-modified syngeneic cells: requirement for Ia-positive Langerhans cells. Journal of Investigative Dermatology 81(3): 208-211, 1983

Autoimmunity induced by injection of virus-modified cell membrane antigens in syngeneic mice. Infection and Immunity 15(1): 322-328, 1977

In vitro generation of helper T cells and suppressor T cells that regulate the cytolytic T lymphocyte response to trinitrophenyl-modified syngeneic cells. Transplantation 33(4): 422-426, 1982

Production and characterization of T-cell clones specific for trinitrophenyl (TNP)-modified syngeneic spleen cells (TNP-self). Indian Journal of Experimental Biology 27(10): 843-848, 1989

T-T-cell interactions during the vitro cytotoxic allograft responses. I. Soluble products from activated Lyl+ T cells trigger autonomously antigen-primed Ly23+ T cells to cell proliferation and cytolytic activity. Journal of Experimental Medicine 148(6): 1523-1538, 1978