+ Translate

The 'presynaptic' blocking potency of sulpiride and haloperidol in the rat is age-dependent

, : The 'presynaptic' blocking potency of sulpiride and haloperidol in the rat is age-dependent. Neuroscience Letters 46(2): 203-207

A low dose of pergolide (0.01 mg/kg) caused a marked inhibition of locomotor activity in male rats. Sulpiride significantly blocked the locomotor inhibition in young (6 weeks of age) rats already in low (2.5 mumol/kg) doses, while in adult (15 weeks of age) rats a blockade was achieved first with high 'postsynaptic' doses (50 mumol/kg). Haloperidol slightly blocked the effect of pergolide in both young and adult rats. However, the blocking action of haloperidol was only found in a narrow pharmacological 'window' (0.05 mumol/kg). This study illustrates the importance of considering age-related variations when using behavioural models of 'presynaptic' dopaminergic agonistic activity. It is suggested that 'presynaptic' dopaminergic events are modulated by hormonal changes during growth.

(PDF 0-2 workdays service)

Accession: 044534928

PMID: 6738914

Submit PDF Full Text: Here

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Related references

Alander T.; Anden N E.; Grabowska Anden M., 1980: Metoclopramide and sulpiride as selective blocking agents of presynaptic and postsynaptic dopamine receptors. The effects of sulpiride and metoclopramide on pre- and postsynaptic dopamine receptors were investigated in the rat brain as antagonism of the apomorphine-induced inhibition of the dopamine synthesis in the absence of nerve impulses and as blocka...

Manani G.; Diani M.M.; Bonaccorso G.; Tresca P.S.; Farnia A.; Narne S.; Cirillo F.M.; Giron G.P., 1987: Reinforcement of the anti emetic activity of domperidone and levo sulpiride by haloperidol validity of the association levo sulpiride and haloperidol. In this study the anti-emetic activity of domperidone, 10 mg i.v., and (-) sulpiride 100 mg i.v., with or without associated haloperidol 0.02 mg .cntdot. kg-1 i.m., was assessed in 60 patients. They were divided into four previously randomized gro...

Suzdak P.D.; Gianutsos G., 1984: Time dependent decrease in brain substance p following long term haloperidol or sulpiride. Substance P-like immunoreactivity (SPLI) was measured in mice receiving haloperidol or sulpiride in their diet for 10 days or 6 wk. A decrease in SPLI was observed in the striatum and mesencephalon of haloperidol-treated mice after either treatmen...

Bass A.S.; Robie N.W., 1984: Stereoselectivity of s sulpiride and r sulpiride for presynaptic and postsynaptic dopamine receptors in the canine kidney. The stereoselectivity of S (S)- and R (R)-sulpiride for the pre- (prereceptor) and post (postreceptor) synaptic dopamine receptors was examined in various tissues. The effects of S and R on the pre- and postreceptor in the canine kidney were inves...

Sugnaux F.R.; Benakis A.; Fonzo D.; D.C.rlo R., 1983: Dose dependent pharmaco kinetics of sulpiride and sulpiride induced prolactin secretion in man. Sulpiride (SU), a widely used benzamide neuroleptic, promotes rapid prolactin [PRL] release. Sulpiride plasma level and the prolactin response to the most commonly used dose, i.e., 50 and 200 mg sulpiride (administered orally), were studied in 10...

Soga H.; Nomura K.; Sokabe M., 1991: Mechanism of voltage dependent blocking by haloperidol of calcium activated potassium channels from rat brain synaptosomal membranes. Japanese Journal of Physiology 41(SUPPL): S161

Lemoine, H.; Ehle, B.; Kaumann, A.J., 1985: Direct labelling of beta 2-adrenoceptors. Comparison of binding potency of 3H-ICI 118,551 and blocking potency of ICI 118,551. A radioligand that selectively labels beta 2-adrenoceptors, 3H-ICI 118,551 (3H-ICI), is introduced. Experiments were performed on guinea-pig tissues. The binding characteristics of 3H-ICI on lung membrane particles are compared with the blocking c...

Shepherd A.M.M.; Kwan C.M.; Carrillo D.W.; Brodie C.L., 1989: Blocking autonomic reflexes does not alter determination of alpha blocking potency of prazosin in humans. Clinical Pharmacology & Therapeutics 45(2): 131

Masuda, Y.; Murai, S.; Yoshida, H.; Saito, H.; Abe, E.; Odashima, J.; Itoh, M.; Itoh, T., 1994: Effects of haloperidol, sulpiride and SCH 23390 on mice memory. Japanese Journal of Pharmacology 64(SUPPL 1): 125P

Cassano, G.B.; Castrogiovanni, P.; Conti, L.; Bonollo, L., 1977: Sulpiride--an antipsychotic agent: comparative trial vs. haloperidol. Psychopharmacology Bulletin 13(3): 41-43