EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
EurekaMag PDF Full Text Supply ServicePDF Full Text Supply Service
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn
Follow on LinkedInFollow on Tumblr

+ Translate

The 'presynaptic' blocking potency of sulpiride and haloperidol in the rat is age-dependent


, : The 'presynaptic' blocking potency of sulpiride and haloperidol in the rat is age-dependent. Neuroscience Letters 46(2): 203-207

A low dose of pergolide (0.01 mg/kg) caused a marked inhibition of locomotor activity in male rats. Sulpiride significantly blocked the locomotor inhibition in young (6 weeks of age) rats already in low (2.5 mumol/kg) doses, while in adult (15 weeks of age) rats a blockade was achieved first with high 'postsynaptic' doses (50 mumol/kg). Haloperidol slightly blocked the effect of pergolide in both young and adult rats. However, the blocking action of haloperidol was only found in a narrow pharmacological 'window' (0.05 mumol/kg). This study illustrates the importance of considering age-related variations when using behavioural models of 'presynaptic' dopaminergic agonistic activity. It is suggested that 'presynaptic' dopaminergic events are modulated by hormonal changes during growth.

(PDF 0-2 workdays service)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 044534928

PMID: 6738914

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Glazer, M.D.; Hill, R.D.; Wenger, N.K., 1985: Dx and Tx of the elderly patient with atherosclerotic coronary heart disease. Complications of MI occur in patients of all ages, but are more common in the elderly. Prevalent are atrial and ventricular dysrhythmias, papillary muscle dysfunction, pericarditis, congestive heart failure, atrioventricular block, cardiogenic sho...

Huang DongMai; Zhu PeiLi; Li QingKang; Yu XiaoHe; Yu Jie, 1997: Hydrophysical characteristics of Vertisol in lowland areas of Jiangsu Province. The morphology, mineralogy, and physical properties of a Vertisol from the title area, China were studied. The structure of the soil profile varied with depth, but profile horizonation was weak, showing an AC profile. Soil clay minerals were domin...

Kleber, Franz X.; Sonntag, Steffen; Krebs, Heike; Stantke, Katrin; Rombeck, Birgit; Konertz, Wolfgang, 2000: Influence of the passive ACORN cardiac support device on systolic and diastolic left ventricular function. Journal of the American College of Cardiology 35(2 suppl A): 182A, Feb

Pittaway, R.; Nero, RW., 1971: Recent bird notes of interest for Churchill, Manitoba. Blue Jay, 29(2): 60-63

Wang, C.; Chen, Y.; Yang, F.; Ren, J.; Yu, X.; Wang, J.; Sun, S., 2016: Efficacy of computer-based endoscope cleaning and disinfection using a hospital management information system. American Journal of Infection Control 44(8): E141-E143

Holick, M.F., 2012: Vitamin D: extraskeletal health. Vitamin D deficiency is the most common nutritional deficiency and likely the most common medical condition in the world. There is a multitude of causes of vitamin D deficiency, but the major cause has been the lack of appreciation that the body r...

Zhu, J.; Bardo, M.T.; Green, T.A.; Wedlund, P.J.; Dwoskin, L.P., 2007: Nicotine increases dopamine clearance in medial prefrontal cortex in rats raised in an enriched environment. Environmental enrichment results in differential behavioral and neurochemical responsiveness to nicotine. The present study investigates dopamine clearance (CL(DA) ) in striatum and medial prefrontal cortex (mPFC) using in vivo voltammetry in rats...

Parsadanian H.K.; Ter Tatevosian L.P.; Martikian H.R.; Avakian S.H., 1989: Changes in the activity of enzymes participating in glycogen metabolism of alloxan diabetic rats. Alloxan diabetes induced in white rats by intraperitoneal injection of alloxan-monohydrate (15 mg/100 g body weight) was used to study changes in the glycogen phosphorylase a and b, phosphoprotein phosphatases and hexakinase activities under insul...

Glaser, Roland; Wollenberger, Albert, 1965: Continuous registration of sodium-22 efflux in human erythrocytes. A method for the continuous registration of the efflux of radioactive sodium from human red cells is described. With the aid of this method it was found that sodium in human red cells is present in three compartments with the following rate exchan...

Teem D.H.; Currey W.L.; Brecke B.J.; Gallaher R.N., 1982: Promoting the use of directed sprays in soybeans floridas usa approach. Proceedings Southern Weed Science Society 35: 376