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The Bucharest multifactorial prevention trial of coronary heart disease. General methodology and risk factor correction after five year follow-up (1971-1977)

Steinbach, M.; Constantineanu, M.; Harnagea, P.; Theodorini, S.; Georgescu, M.; Mitu, S.; Tănăseanu, S.; Tănăsescu, C.; Teodorescu, S.; Voiculescu, M.; Voiosu, R.; Cucu, F.; Suciu, A.; Schioiu, L.; Ciobanu, F.; Chirulescu, Z.; Schiau, M.; Cherciu, M.; Stoica, V.; David, D.; Stănescu, C.; Stefănescu, S.; Ionescu, A.

Medecine Interne 20(2): 117-136

1982


ISSN/ISBN: 0377-1202
PMID: 7123111
Accession: 044538663

Both the intervention and the control group included each 5000 men aged 40-60 years, randomly selected by their home address in five districts of the city of Bucharest. The intervention group underwent an "at entry" examination for risk factor detection (high serum cholesterol, high blood pressure, overweight, diabetes, minor ECG abnormalities, family history) and subsequently a five-year multifactorial intervention aimed to reduce the risk factors. Both groups were followed up in this lapse of time for major end-points: myocardial infarction, stroke, sudden death. The qualitative analysis of the results used ten evolution indices based on a quantal counting and lead to a classification of risk factors which allowed the setting up of a strategy for their correction. The quantitative analysis showed the following decreases between the first and the last examination in the intervention group: for serum cholesterol greater than or equal to 250 mg/dl -17%; for cigarettes/day greater than or equal to 15-53%; for overweight greater than or equal to 30% - 13.57%; for high blood pressure -8%; for the overall risk computed by multiple regression -33.8%.

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