+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The agouti suppressor (As) coat color mutation in mice: developmental effects on the expression of agouti locus alleles



The agouti suppressor (As) coat color mutation in mice: developmental effects on the expression of agouti locus alleles



Journal of Experimental Zoology 220(1): 57-64



The alleles at the agouti locus in the mouse determine whether eumelanin or pheomelanin is synthesized by the follicular melanocytes. The agouti suppressor (As) mutation, which is closely linked to the agouti locus, reduces the amount of pheomelanin produced by whatever agouti alleles are present in the animal's genome. Previous developmental studies have indicated that the agouti alleles exert their influence on the follicular melanocytes via interactions between the developing dermis and epidermis. Using the techniques of dermal-epidermal recombination of embryonic agouti suppressor (AsAw/AsAw), white-bellied agouti (Aw/Aw), yellow (Ay/a), viable yellow (Avy/Avy), black and tan (at/at), and nonagouti (a/a) mouse skin, the present study demonstrates that 1) the dermis is responsible for the development of regional pigmentation patterns in white-bellied agouti mice, and 2) the agouti suppressor mutation interferes with the expression of the white-bellied agouti allele by acting on the dermis as well as the epidermis. In addition, this study provides further evidence for the role of the epidermis in the expression of the agouti locus alleles.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 044556071

Download citation: RISBibTeXText

PMID: 7077265

DOI: 10.1002/jez.1402200108


Related references

Hair pigment patterns in different integumental environments of the mouse influence of the agouti suppressor a s mutation on expression of agouti locus alleles. Journal of Heredity 71(4): 229-234, 1980

Hypervariable yellow (Ahvy), a new murine agouti mutation: Ahvy displays the largest variation in coat color phenotypes of all known agouti alleles. Journal of Heredity 86(2): 121-128, 1995

A mutation at the agouti locus is associated with recessive black coat color in sheep. Journal of Animal Science 79(Suppl. 2): 124, 2001

Dermal epidermal interactions and the action of alleles at the agouti locus in the mouse 2. the viable yellow a v y and mottled agouti a m alleles. Developmental Biology 80(2): 495-500, 1980

Effects of alleles at the agouti locus on minor skeletal variants in C57BL/6 house mice. Genetical Research 47(1): 35-41, 1986

Effects of alleles at the agouti locus on behavioral traits in the c 57bl 6hb strain of house mice. Behavior Genetics 7(1): 54, 1977

Molecular markers for the agouti coat color locus of the mouse. Genetics 115(4): 747-754, 1987

The agouti coat-color locus may influence brain catecholamines: Regional differences in norepinephrine and dopamine in the brains of two color-morphs of deermice (Peromyscus maniculatus). Comparative Biochemistry and Physiology C Pharmacology Toxicology and Endocrinology 107(1): 51-55, 1994

The alpaca agouti gene: genomic locus, transcripts and causative mutations of eumelanic and pheomelanic coat color. Gene 521(2): 303-310, 2013

Pheomelanin production in the epidermis from newborn agouti mice is induced by the expression of the agouti gene in the dermis. Pigment Cell Research 17(5): 506-514, 2004

Recombinant inbred strain interspecific backcross analysis of molecular markers flanking the murine agouti coat color locus. Genetics 122(3): 669-680, 1989

Recombinant inbred strain and interspecific backcross analysis of molecular markers flanking the murine agouti coat color locus. Genetics 122(3): 669-679, 1989

Use of the principle of interspecific homology in studying the genetics of coat color in domestic ruminants: the Agouti locus as an illustration Cattle, sheep, goats.1. Bulletin de la Societe zoologique de France08(2): 231-243, 1983

Levels of tyrosinase and its mRNA in coat-color mutants of C57BL/10J congenic mice: effects of genic substitution at the agouti, brown, albino, dilute, and pink-eyed dilution loci. Journal of Experimental Zoology 250(3): 304-311, 1989

Coat Color in Intact and Neurointermediate Lobe-Grafted Agouti Mice: Effect of Dopamine Agonists and Antagonists. Neuroendocrinology 35(3): 194-199, 1982