+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

The effect of age and sex on glutathione reductase and glutathione peroxidase activities and on aerobic glutathione oxidation in rat liver homogenates



The effect of age and sex on glutathione reductase and glutathione peroxidase activities and on aerobic glutathione oxidation in rat liver homogenates



Biochemical Journal 112(1): 109-115



1. Changes in liver glutathione reductase and glutathione peroxidase activities in relation to age and sex of rats were measured. Oxidation of GSH was correlated with glutathione peroxidase activity. 2. Glutathione reductase activity in foetal rat liver was about 65% of the adult value. It increased to a value slightly higher than the adult one at about 2-3 days, decreased until about 16 days and then rose after weaning to a maximum at about 31 days, finally reaching adult values at about 45 days old. 3. Weaning rats on to an artificial rat-milk diet prevented the rise in glutathione reductase activity associated with weaning on to the usual diet high in carbohydrate. 4. In male rats glutathione peroxidase activity in the liver increased steadily up to adult values. There were no differences between male and female rats until sexual maturity, when, in females, the activity increased abruptly to an adult value that was about 80% higher than that in males. 5. The rate of GSH oxidation in rat liver homogenates increased steadily from 3 days until maturity, when the rate of oxidation was about 50% higher in female than in male liver. 6. In the liver a positive correlation between glutathione peroxidase activity and GSH oxidation was found. 7. It is suggested that the coupled oxidation-reduction through glutathione reductase and glutathione peroxidase is important for determining the redox state of glutathione and of NADP, and also for controlling the degradation of hydroperoxides. 8. Changes in glutathione reductase and glutathione peroxidase activities are discussed in relation to the redox state of glutathione and NADP and to their effects on the concentration of free CoA in rat liver and its possible action on ketogenesis and lipogenesis.

(PDF emailed within 0-6 h: $19.90)

Accession: 044603530

Download citation: RISBibTeXText

PMID: 4388243

DOI: 10.1042/bj1120109


Related references

Effect of storage temperature on the activity of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione S-transferase in rat liver and kidney homogenates. Enzyme and Protein 47(3): 149-155, 1993

Effect of common bile duct ligation on the liver glutathione s transferase glutathione peroxidase and glutathione reductase activities in ethanol intoxicated rats. Korean Biochemical Journal 23(2): 251-262, 1990

The effects of exogenous glutathione on reduced glutathione level, glutathione peroxidase and glutathione reductase activities of rats with different ages and gender after whole-body Γ-irradiation. Journal of the American Aging Association 26(3-4): 55-58, 2003

Glutathione s transferase and glutathione peroxidase activities during the state of glutathione depletion leading to lipid per oxidation in rat liver. Research Communications in Chemical Pathology & Pharmacology 37(2): 163-170, 1982

Effect of ischaemia-reperfusion on glutathione peroxidase, glutathione reductase and glutathione transferase activities in human heart protected by hypothermic cardioplegia. Free Radical Research Communications 8(2): 85-91, 1990

Effect of selenium pre treatment on the tissue sulfhydryl groups glutathione reductase glutathione peroxidase and glutathione s transferase activities in rats intoxicated with cadmium. Korean Journal of Biochemistry 13(2): 180, 1981

Glutathione peroxidase and glutathione reductase activities from rat liver under the effect of the synthetic pyrethroid deltamethrin. Bulgarian Journal of Agricultural Science 4(1): 105-110, 1998

The effect of melatonin on glutathione and glutathione transferase and glutathione peroxidase activities in the mouse liver and kidney in vivo. Neuro Endocrinology Letters 27(3): 365-368, 2006

The influence of road transport on the activities of glutathione reductase, glutathione peroxidase, and glutathione-S-transferase in equine erythrocytes. Veterinary Clinical Pathology 41(1): 123-126, 2012

Glutathione peroxidase, glutathione S-transferase and glutathione reductase activities in normal and neoplastic human breast tissue. Cancer Letters 29(1): 37-42, 1985

Subcellular localization and modification with aging of glutathione glutathione peroxidase and glutathione reductase activities in human fibroblasts. Biochimica et Biophysica Acta 838(2): 211-220, 1985

Glutathione peroxidase glutathione reductase and glutathione transferase activities in the human artery vein and heart. Journal of Molecular & Cellular Cardiology 22(9): 935-938, 1990

Effects of fluoroquinolones on activities of glutathione S-transferase, glutathione reductase and glutathione peroxidase in extrahepatic tissues. Zhongguo Kangshengsu Zazhi 30(7): 423-425,448, 2005

Glutathione peroxidase, glutathione reductase and glutathione-S-transferase activities in the rhesus monkey lens as a function of age. Current Eye Research 5(3): 195-199, 1986

Glutathione peroxidase glutathione reductase and glutathione s transferase activities in the rhesus monkey macaca mulatta lens as a function of age. Current Eye Research 5(3): 195-200, 1986