The fate of N-nitrosodiethanolamine after oral and topical administration to rats
Lethco, E.J.; Wallace, W.C.; Brouwer, E.
Food and Chemical Toxicology An International Journal Published for the British Industrial Biological Research Association 20(4): 401-406
ISSN/ISBN: 0278-6915 PMID: 6890019 DOI: 10.1016/s0278-6915(82)80104-x
14C-labelled N-nitrosodiethanolamine ([14C]NDELA) was given to Osborne-Mendel rats at two dose levels, 0.5 or 50 mg/kg, by oral or topical administration. The excreta and tissues were analysed at various times from 4 hr to 1 wk after administration to determine the distribution of radioactivity. After oral administration, [14C]NDELA was rapidly absorbed from the gastro-intestinal tract, distributed throughout all organs and tissues, and then excreted, mainly via the kidneys. The tissue concentration reached a peak at 8 hr, but some activity remained after 1 wk. After topical application NDELA was slowly absorbed percutaneously, but once absorbed was distributed as in the orally dosed rats. Metabolic profiles of urine and bile samples from both the orally and topically dosed rats were identical, although the quantities varied. In addition to unchanged NDELA, one metabolite was present. The dose level had little effect on the quantities of unchanged NDELA or the metabolite present.