+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The free fraction of valproic acid in tears, saliva, and cerebrospinal fluid

The free fraction of valproic acid in tears, saliva, and cerebrospinal fluid

Epilepsia 23(1): 23-26

Valproic acid (VPA) was determined by EMIT assay in plasma, tears, saliva, and cerebrospinal fluid (CSF) of patients with epilepsy. Closer correlation was shown between tear/plasma and tear/CSF ratios than between saliva/plasma and saliva/CSF ratios. The VPA CSF/serum ratio was in good agreement with data in the literature. Salivary levels were extremely erratic, while those for tears were much more reliable. Determination of VPA in tears is therefore the best method of studying the VPA free fraction in those cases in which investigations of protein binding of the drug are necessary.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 044643540

Download citation: RISBibTeXText

PMID: 6799283

Related references

Distribution of valproic acid in serum cerebrospinal fluid and saliva. Electroencephalography & Clinical Neurophysiology 60(2): 43P, 1985

Assessment of tear concentrations on therapeutic drug monitoring. II. Pharmacokinetic analysis of valproic acid in guinea pig serum, cerebrospinal fluid, and tears. Pharmaceutical Research (New York) 18(4): 500-509, 2001

A study on cerebrospinal fluid and saliva to serum concentration ratios of anticonvulsants--Phenytoin, Phenobarbital, Valproic Acid and Primidone in epileptic patients. Seishin Shinkeigaku Zasshi 84(9): 661-679, 1982

Concentrations of zonisamide in serum, free fraction, mixed saliva and cerebrospinal fluid in epileptic children treated with monotherapy. Japanese Journal of Psychiatry and Neurology 47(2): 291-292, 1993

Ethosuximide in tears, saliva, and cerebrospinal fluid. Therapeutic Drug Monitoring 3(4): 321-323, 1981

Pharmacokinetics of cytosine arabinoside, methotrexate, nimustine and valproic acid in cerebrospinal fluid during cerebrospinal fluid perfusion chemotherapy. Biological & Pharmaceutical Bulletin 23(6): 784-787, 2000

Occurrence of poliocidal substances in tears, saliva and cerebrospinal fluid of normal individuals. Proc Soc Exp Biol And Med 32(9): 1534-1537, 1935

Multiple sclerosis Immunological screening of 4 fluids Cerebrospinal fluid, serum, saliva and tears. Journal of the Neurological Sciences 150(SUPPL ): S322, 1997

Free fraction of valproic acid: in vitro time-dependent increase and correlation with free fatty acid concentration in human plasma and serum. Epilepsia 24(1): 65-73, 1983

The disposition of valproic acid in plasma saliva and spinal fluid. Clinical Pharmacology & Therapeutics 23(1): 115, 1978

The effect of valproic acid on the 5-hydroxyindoleacetic, homovanillic and lactic acid levels of cerebrospinal fluid. Brain Research 420(2): 268-276, 1987

Therapeutic carbamazepine (Cbz) and valproic acid (Vpa) monitoring in children using saliva as a biologic fluid. Journal of Epilepsy and Clinical Neurophysiology 14(2): 55-58, 2008

Valproic acid binding to human serum albumin and determination of free fraction in the presence of anticonvulsants and free fatty acids. Epilepsia 20(1): 85-90, 1979

Clearance of valproic acid from cerebrospinal fluid in anesthetized rabbit. Journal of Neurosurgical Anesthesiology 6(3): 193-200, 1994

Correlation of saliva and serum free valproic acid concentrations in persons with epilepsy. Seizure 25: 187-190, 2015