+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The impact of legal termination of pregnancy and of prenatal diagnosis on the birth prevalence of Down syndrome in Denmark

The impact of legal termination of pregnancy and of prenatal diagnosis on the birth prevalence of Down syndrome in Denmark

Annals of Human Genetics 47(Pt 2): 123-131

A considerable reduction in number of livebirths for mothers over 35 was observed in Denmark from 1960 to 1980. Birthrates for those aged 35-39 fell by 58.8%, for those aged 40-44 by 78%. In 1979-1980 100 infants with Down syndrome were born among 116757 newborns, a birth prevalence of 0.86 per 1000, which was significantly lower than the incidence of 1.17 per 1000 when the prenatally diagnosed cases were included. The reduction was noticeable for the age group over 35 where it fell to 1.89 per 1000 for mothers 35-39 and 6.48 per 1000 for mothers over 40. The utilization of prenatal diagnosis was 72 per 100 livebirths for women 35 and older in the Copenhagen area and 56 per 100 livebirths for the rest of the country, with differences in different areas. The number of induced abortions for women 35 years and older was 9265 against 6597 livebirths. The estimated number of Down syndrome cases averted by unrestricted abortion was 61, twice the number prevented by amniocentesis (31), with the greatest impact for mothers over 40. An increased risk of Down syndrome for the age group 35-39 was observed when liveborn and prenatal cases were considered together showing an incidence of 6.89 per 1000, with the highest incidence in the Copenhagen area, 8.70 per 1000, more than double the incidence of 3.04 observed in Copenhagen from 1960 to 1971, for the same age group.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 044656159

Download citation: RISBibTeXText

PMID: 6224457

DOI: 10.1111/j.1469-1809.1983.tb00979.x

Related references

Prevalence and distribution of congenital cardiopathy at birth and in pregnancy termination: impact of prenatal diagnosis in 4 years of experience. Acta Bio-Medica de L'ateneo Parmense 71 Suppl 1(): 487-492, 2001

The impact of prenatal diagnosis on the birth prevalence of malformed children in a region without upper limit for termination of pregnancy. American Journal of Human Genetics 73(5): 591, 2003

Impact of prenatal diagnosis and elective termination on the prevalence of selected birth defects in Hawaii. American Journal of Epidemiology 148(12): 1206-1211, 1998

The impact of prenatal diagnosis and termination of pregnancy on the relative incidence of malformations at birth among Jews and Muslim Arabs in Israel. Israel Medical Association Journal 12(9): 539-542, 2011

Prenatal detection of birth defects in a Malaysian population: estimation of the influence of termination of pregnancy on birth prevalence in a developing country. Australian and New Zealand Journal of Obstetrics and Gynaecology 46(1): 55-57, 2006

Prenatal diagnosis of hypoplastic left heart syndrome: impact of counseling patterns on parental perceptions and decisions regarding termination of pregnancy. Pediatric Cardiology 33(8): 1402-1410, 2013

Recent trends in the birth prevalence of Down syndrome in China: impact of prenatal diagnosis and subsequent terminations. Prenatal Diagnosis 35(4): 311-318, 2016

Trends in live birth prevalence of down syndrome in the Northern Netherlands 1987-96: the impact of screening and prenatal diagnosis. Prenatal Diagnosis 20(9): 709-713, 2000

Awareness and attitude toward prenatal diagnosis of chromosomal abnormalities in patients with no access to legal termination of pregnancy. Prenatal Diagnosis 26(10): 885-891, 2006

Prenatal genetic diagnosis and elective abortion in women over 35: utilization and relative impact on the birth prevalence of Down syndrome in Washington State. American Journal of Medical Genetics 7(3): 375-381, 1980

Termination of pregnancy after prenatal diagnosis of cleft lip and palate--possible influence on reports of prevalence. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics 107(6): 759-762, 2009

Has noninvasive prenatal testing impacted termination of pregnancy and live birth rates of infants with Down syndrome?. Prenatal Diagnosis 37(13): 1281-1290, 2017

Has Noninvasive Prenatal Testing Impacted Termination of Pregnancy and Live Birth Rates of Infants With Down Syndrome?. Obstetrical & Gynecological Survey 73(5): 269-270, 2018

The impact of prenatal diagnosis and pregnancy termination on overall infant mortality in Canada. Paediatric and Perinatal Epidemiology 15(4): A21-A22, 2001

Influence of prenatal diagnosis and pregnancy termination of fetuses with birth defects on the perinatal mortality rate in Victoria, Australia. Paediatric and Perinatal Epidemiology 19(1): 50-55, 2005