Section 45
Chapter 44,659

The importance of the position of the adenosine linkage in NAD+ for its coenzyme activity via lactate dehydrogenase

Schlimme, E.; Mattern, R.; Schott, E.

Zeitschrift für Naturforschung. Section C Biosciences 37(3-4): 342-344


ISSN/ISBN: 0341-0382
PMID: 7072317
Accession: 044658344

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We report on the chemical preparation of the NAD+ analog P1, P2-(5'-beta-nicotinamideribofuranosyl-3"-adenosyl)-diphosphate (N3"AD+) by applying the 1,1'-carbonyldiimidazole activation method. The importance of how adenosine is linked to the nicotinamide mononucleotide phosphoriboride (NMNPR+) moiety is discussed with respect to the coenzyme activity in the lactate dehydrogenase catalyzed reaction.

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