+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The metabolism of mianserin in women, rabbits, and rats: identification of the major urinary metabolites



The metabolism of mianserin in women, rabbits, and rats: identification of the major urinary metabolites



Drug Metabolism and Disposition: the Biological Fate of Chemicals 9(1): 48-53



The biotransformation of orally administered 3H-mianserin was investigated in female human subjects, rabbits, and rats by identification of the major urinary metabolites. Three days after dosing, the urinary excretion of radioactivity was 53% in women, 36% in rats, and 80% in rabbits. In the women's urine, 15% of the administered dose was excreted in the form of mianserin (conjugated plus nonconjugated); in the animal species this quantity was 1-2%. Mianserin was predominantly metabolized to 8-hydroxy analogs in all species; in rats, 8-hydroxydesmethylmianserin was the principal metabolite. Demethylation was an important metabolic pathway in the animal species, but not in women. Novel N-formyl compounds were detected in the urine of both animal species, but the possibility that these were artifacts formed during extraction with chloroform cannot be ruled out. Trace amounts of two compounds in which the piperazine moiety of mianserin was absent, 11H-dibenz[b,e]azepine and 11 H-dibenz[b,e]azepine-2-ol, were identified in the urine of rabbits and rats, respectively.

Please choose payment method:






(PDF emailed within 1 workday: $29.90)

Accession: 044684911

Download citation: RISBibTeXText

PMID: 6111431


Related references

Metabolism of mianserin in women rabbits and rats identification of the major urinary metabolites. Drug Metabolism & Disposition 9(1): 48-53, 1981

The metabolism of the retinoid ro 10 9359 isolation and identification of the major metabolites in human plasma urine and feces synthesis of 3 urinary metabolites. Helvetica Chimica Acta 60(7): 2309-2325, 1977

Identification of major biliary and urinary metabolites of ecabapide in rats. Xenobiotica; the Fate of Foreign Compounds in Biological Systems 26(9): 983-994, 1996

Identification of urinary metabolites of em 12 n 2' 6' di oxopiperiden 3' yl phthalimidine a teratogenic analog of thalidomide in rats and rabbits. Canadian Journal of Pharmaceutical Sciences 15(2): 21-23, 1980

Isolation and identification of major urinary metabolites of rifabutin in rats and humans. Drug Metabolism and Disposition: the Biological Fate of Chemicals 25(8): 963-969, 1997

Identification of the major urinary and fecal metabolites of 3,5-dinitrobenzamide in chickens and rats. Chemosphere 38(8): 1757-1762, 1999

L-Bunolol metabolism in rats: identification of urinary metabolites. Journal of Pharmaceutical Sciences 67(1): 129-131, 1978

Metabolism of adiphenine 2. identification of major excretion metabolites in rats. Xenobiotica 12(7): 457-462, 1982

Metabolism of adiphenine. Ii. Identification of major excretion metabolites in rats. Xenobiotica 12(7): 457-462, 1982

In vivo metabolism of Î -methyltryptamine in rats: Identification of urinary metabolites. Xenobiotica 38(12): 1476-1486, 2008

In vivo metabolism of alpha-methyltryptamine in rats: identification of urinary metabolites. Xenobiotica; the Fate of Foreign Compounds in Biological Systems 38(12): 1476-1486, 2008

Study on the metabolism of 5,6-methylenedioxy-2-aminoindane (MDAI) in rats: identification of urinary metabolites. Xenobiotica; the Fate of Foreign Compounds in Biological Systems 47(6): 505-514, 2017

Metabolism of drugs. LXXII. Synthesis of nalorphine-3- and -6-glucuronide and identification of urinary metabolites of nalorphine in rabbits. Chemical and Pharmaceutical Bulletin 18(12): 2548-2554, 1970

Metabolism and distribution of [2,3-14C]acrolein in Sprague-Dawley rats. II. Identification of urinary and fecal metabolites. Toxicological Sciences 43(2): 110-120, 1998

Metabolism of metandienone in man: Identification and synthesis of conjugated excreted urinary metabolites, determination of excretion rates and gas chromatographic-mass spectrometric identification of bis-hydroxylated metabolites. The Journal of Steroid Biochemistry and Molecular Biology 38(4): 441-464, 1991