+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The possible site of action of 5-hydroxytryptamine, 6-hydroxytryptamine, tryptamine and dopamine on identified neurons in the central nervous system of the snail, Helix aspersa



The possible site of action of 5-hydroxytryptamine, 6-hydroxytryptamine, tryptamine and dopamine on identified neurons in the central nervous system of the snail, Helix aspersa



Comparative Biochemistry and Physiology. C Comparative Pharmacology and Toxicology 78(1): 217-225



Intracellular recordings were made from identified neurons in the right parietal ganglion of the snail, Helix aspersa. Cells F 4, 5 and 6 were excited by 5-hydroxytryptamine (5-HT) and inhibited by dopamine while cells in the F 30 area were inhibited by both compounds. Low doses of both tryptamine and 6-HT produced weak excitation of cells F 4, 5 and 6 while higher doses of both compounds inhibit the activity of these cells. In terms of the inhibitory responses, tryptamine and 6-HT are approximately equipotent but between 10 and 100 times less potent than dopamine. d-Tubocurarine reversibly antagonized the excitatory action of 5-HT on cells F 4, 5 and 6 and converted tryptamine and 6-HT excitation to inhibition. In the presence of the antagonist, ergometrine, the dopamine inhibitory response was almost completely abolished while the inhibitory responses to tryptamine and 6-HT were converted to weak excitation. All four agonists inhibited cells in the F 30 area with the following potency ratios: dopamine much greater than tryptamine/6-HT greater than 5-HT. Tubocurarine had no antagonist effects on these responses while ergometrine reduced or blocked all four, often irreversibly. In potassium-free Ringer the inhibitory responses to all four agonists were enhanced. It is concluded that on cells F 4, 5 and 6, low concentrations of tryptamine and 6-HT act on 5-HT receptors while higher concentrations of both agonists act on dopamine receptors. On cells in the F 30 area, 5-HT, 6-HT and tryptamine all act on a dopamine receptor.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 044710857

Download citation: RISBibTeXText

PMID: 6146474

DOI: 10.1016/0742-8413(84)90073-2


Related references

Effects of 5,7-dihydroxytryptamine on an identified 5-hydroxytryptamine-containing neurone in the central nervous sytem of the snail Helix pomatia. British Journal of Pharmacology 56(1): 29-38, 1976

The effect of the herbicide Azafenidin on action potential generation in identified central neurons of the snail Helix aspersa. Society for Neuroscience Abstracts 27(1): 391, 2001

Investigations into the role of cGMP and nitric oxide in the action of GSPYFVamide on identified central neurons of the snail, Helix aspersa. Journal of Physiology (Cambridge) 495P: 39P-40P, 1996

The active uptake of 5-hydroxytryptamine in snail (Helix pomatia) central nervous system and its energy source. Biochemical Society Transactions 5(1): 178-179, 1977

Actions of cholecystokinin on neurons in the central nervous system of the snail helix aspersa. Comparative Biochemistry & Physiology C Comparative Pharmacology 75(1): 171-178, 1983

Distribution of CDCP-immunoreactive neurons in the central nervous system of the snail Helix aspersa. Reproduction Nutrition Development 322: 113-121, 1992

Localization of arginine vasopressin like material in central neurons and mechanism of action of arginine vasotocin on identified neurons of the snail helix aspersa. Neuropharmacology 26(11): 1633-1648, 1987

Distribution of alpha CDCP-immunoreactive neurons in the central nervous system of the snail Helix aspersa. Reproduction Nutrition Development 32(2): 113-121, 1992

Cyclic amp production in the central nervous system of the snail lymnaea stagnalis is stimulated by forskolin and 5 hydroxytryptamine but is not affected by dopamine. Comparative Biochemistry & Physiology C Pharmacology Toxicology & Endocrinology 95(2): 163-168, 1990

Neuropharmacological studies on identified central neurons of the snail Helix aspersa. Zhurnal Vysshei Nervnoi Deyatel'nosti Imeni I P Pavlova 43(1): 109-120, 1993

The effect of dextro tubocurarine on the responses of snail helix aspersa neurons to acetyl choline 5 hydroxy tryptamine glutamate and dopamine receptors or ionophores?. Comparative Biochemistry & Physiology C Comparative Pharmacology 64(1): 101-114, 1979

Investigation of neurons identified in the central nervous system of the snail helix pomatia. Acta Physiologica Academiae Scientiarum Hungaricae 48(2/3): 178, 1976

Histochemical studies on the effect of (positive)-amphetamine, drugs of the imipramine group and tryptamine on central catecholamine and 5-hydroxytryptamine neurons after intraventricular injection of catecholamines and 5-hydroxytryptamine. European Journal of Pharmacology 4(2): 135-144, 1968

The ionic mechanism associated with the action of putative transmitters on identified neurons of the snail, Helix aspersa. Comparative Biochemistry and Physiology. C Comparative Pharmacology and Toxicology 84(2): 231-241, 1986

The ionic mechanism associated with the action of putative transmitters on identified neurons of snail, Helix aspersa. Comparative Biochemistry and Physiology C Comparative Pharmacology 842: 231-241, 1986