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The presynaptic effects of aspirin and prostaglandin E2 in the isolated cat heart


, : The presynaptic effects of aspirin and prostaglandin E2 in the isolated cat heart. Brazilian Journal of Medical and Biological Research 16(2): 133-140

The presynaptic effects of aspirin and prostaglandin E2 (PGE2) were evaluated in the isolated perfused cat heart preparation. Tissue catecholamine stores were studied by labelling the sympathetic nerve endings with [3H]-noradrenaline ([3H]-NA) and the effect of electric neural stimulation (5 Hz, 0.5 ms, 8 V, 60 s) was determined in the presence of drugs which inhibit neuronal or extraneuronal uptake, or antagonize alpha-adrenoceptors. [3H]-NA overflow was significantly increased by electric neural stimulation. Perfusion with 0.1 microM phentolamine increased transmitter overflow. Infusion of 0.1 microM PGE2 reduced the [3H]-NA overflow induced by electrical stimulation. Administration of 1 microM aspirin increased the [3H]-NA overflow and PGE2 prevented this effect of aspirin. The results support the view that PGEs participate in the negative feedback of transmitter release in the isolated perfused cat heart.


Accession: 044714450

PMID: 6317103

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Related references

Foerster W.; Mentz P., 1973: Effects of prostaglandin e 1 prostaglandin e 2 and prostaglandin f 2 alpha on isolated normal and damaged heart preparations. Bergstrom, S (Ed ) Advances in The Biosciences, Vol 9 International Conference on Prostaglandis Vienna, Austria, Sept 25-28, 1972 Xv+887p Illus Pergamon Press: Oxford, England; New York, N Y , U S A 379-384

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Berti, F.; Lentati, R.; Usardi, M.M., 1965: The Species Specificity Of Prostaglandin E 1 Effects On Isolated Heart. Purified prostaglandin E1 (PGE1) is tested on isolated heart from the cat, rabbit, rat, guinea-pig and frog. The last 2 preparations are very sensitive to low doses of PGE1 (0.1-1 [mu]g, direct injection). The effects induced are increased heart r...

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