+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

The time course of protection from delayed neurotoxicity induced by tri-o-cresyl phosphate and O,O-diisopropyl phosphorofluoridate by phenyl methyl sulfonyl fluoride in chickens

The time course of protection from delayed neurotoxicity induced by tri-o-cresyl phosphate and O,O-diisopropyl phosphorofluoridate by phenyl methyl sulfonyl fluoride in chickens

Toxicology Letters 18(3): 251-256

The time dependence of the ability of phenyl methyl sulfonyl fluoride (PMSF) to protect adult hens from developing signs of paralysis following the administration of 750 mg/kg tri-ortho-cresyl phosphate (TOCP), p.o., of 1.7 mg/kg O,O-diisopropyl phosphorofluoridate (DFP), s.c., was investigated. PMSF was able to protect the hens from organophosphorus-induced delayed neurotoxicity (OPIDN) when given between 1 and 24 h before the administration of TOCP, or when given 4 h before DFP. However, PMSF was ineffective at preventing paralysis when given 24 h following dosing with TOCP or when given later than 4 h before DFP administration. These results support the notion that PMSF acts at the same site as the organophosphorus esters.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 044766170

Download citation: RISBibTeXText

PMID: 6665797

DOI: 10.1016/0378-4274(83)90102-9

Related references

The time course of protection from delayed neuro toxicity induced by tri o cresyl phosphate and dfp by phenylmethylsulfonyl fluoride in chickens. Toxicology Letters 18(3): 251-256, 1983

Absence of a protective effect of corticosterone on 0-0-diisopropyl phosphorofluoridate (DFP) induced delayed neurotoxicity in chickens. Neurotoxicology 6(1): 87-92, 1985

Pathological changes in nervous system of chickens in tri-ortho-cresyl-phosphate (TOCP) induced delayed neurotoxicity. Indian Journal of Environment and Toxicology 11(2): 65-67, 2001

Protein levels of neurofilament subunits in the hen central nervous system following prevention and potentiation of diisopropyl phosphorofluoridate (DFP)-induced delayed neurotoxicity. Biochemical Pharmacology 63(1): 11-19, 2002

Effect of prevention and potentiation of diisopropyl phosphorofluoridate (DFP)-induced delayed neurotoxicity on the mRNA expression of neurofilament subunits in hen central nervous system. Biochemistry and Cell Biology 79(2): 207-217, 2001

Potentiation of organophosphorus-induced delayed neurotoxicity following phenyl saligenin phosphate exposures in 2-, 5-, and 8-week-old chickens. Fundamental & Applied Toxicology 37(1): 64-70, 1997

Autophagy in Tri-o-cresyl Phosphate-Induced Delayed Neurotoxicity. Journal of Neuropathology and Experimental Neurology 76(1): 52-60, 2017

The relationship of tri o cresyl phosphate induced delayed neurotoxicity to increased in vitro. Federation Proceedings 44(3): 515, 1985

The homeostasis of phosphatidylcholine and lysophosphatidylcholine was not disrupted during tri-o-cresyl phosphate-induced delayed neurotoxicity in hens. Toxicology 252(1-3): 56-63, 2008

Relationship of tri-O-cresyl phosphate-induced delayed neurotoxicity to enhancement of in vitro phosphorylation of hen brain and spinal cord proteins. Journal of Pharmacology and Experimental Therapeutics 239(2): 597-605, 1986

Screening the proteins of organophosphoms ester-induced delayed neurotoxicity in the cerebral tissue of hens exposed to tri-ortho-cresyl phosphate. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 29(5): 364-366, 2011

Effect of tri-o-cresyl phosphate, tri-o-cresyl thiophosphate and 2-(o-cresyl)-4H :1:3:2 benzodioxaphosphoran-2-one on pentobarbital induced sleeping time in mice. Archives Internationales de Pharmacodynamie et de Therapie 172(2): 373-379, 1968

Phenylmethylsulfonyl fluoride protects against the degradation of neurofilaments in tri-ortho-cresyl phosphate (TOCP) induced delayed neuropathy. Toxicology 262(3): 258-264, 2009

Organophosphate induced delayed neuropathy in genetically dissimilar chickens: studies with tri-ortho-cresyl phosphate (TOCP) and trichlorfon. Toxicology Letters 136(2): 143-150, 2002

Possible neurotoxicity of diisopropyl phosphorofluoridate in guinea-pigs. Nature 209(5027): 1032, 1966