+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Treatment with propylthiouracil before radioactive iodine therapy is associated with a higher treatment failure rate than therapy with radioactive iodine alone in Graves' disease



Treatment with propylthiouracil before radioactive iodine therapy is associated with a higher treatment failure rate than therapy with radioactive iodine alone in Graves' disease



Thyroid 5(4): 243-247



Older reports have suggested that the use of antithyroid drugs with radioactive iodine-131 (RAI) results in higher rates of persistent hyperthyroidism than treatment with RAI alone. Our objective was to determine if propylthiouracil (PTU) given prior to RAI would be associated with a higher single dose RAI failure rate than treatment with RAI alone. Patients were considered treatment failures if a second dose of RAI was required to produce euthyroidism or hypothyroidism. All study patients stopped PTU at least 4 days before RAI therapy and did not receive PTU after RAI. The overall failure rate of one course of treatment in the 86 study patients was 17% (15/86). Persistent hyperthyroidism was seen in 4% of patients (2/48) treated with only RAI and in 34% of patients (13/38) receiving RAI after pretreatment with PTU (p = 0.003). Patients were treated with PTU for a mean of 151 +/- 32 days. There were no significant differences in race, gender, thyroid size, RAI dose, or days of follow-up between patients receiving RAI alone and those receiving PTU before RAI therapy. These data suggest that pretreatment with PTU leads to a higher failure rate even if PTU is discontinued at least 4 days before RAI therapy and not restarted after RAI dosing. Consideration should be given to increasing the dose of RAI in patients pretreated with PTU to ensure adequate treatment of Graves' disease.

(PDF emailed within 0-6 h: $19.90)

Accession: 044865699

Download citation: RISBibTeXText

PMID: 7488862

DOI: 10.1089/thy.1995.5.243


Related references

The effect of propylthiouracil on subsequent radioactive iodine therapy in Graves' disease. Clinical Endocrinology 47(4): 425-430, 1997

Radioactive iodine in the study of thyroid physiology; the use of radioactive iodine therapy in Graves' disease. Western Journal of Surgery, Obstetrics, and Gynecology 54(12): 474-486, 2011

Accuracy considerations when using early (four- or six-hour) radioactive iodine uptake to predict twenty-four-hour values for radioactive iodine dosage in the treatment of Graves' disease. Thyroid 10(9): 779-787, 2000

Nodular pretibial myxoedema after treatment of Graves disease with radioactive iodine ablation therapy. BMJ Case Reports 2014, 2014

Influence of an additional application of iodine-127 on the pharmacokinetics of radioactive iodine-131 during a radioiodine therapy in patients with Graves disease. Journal of Nuclear Medicine 44(5 Suppl.): 332P-333P, 2003

Evidence for higher success rates and successful treatment earlier in Graves' disease with higher radioactive iodine doses. Thyroid 22(10): 991-995, 2013

Prediction of post-treatment hypothyroidism using changes in thyroid volume after radioactive iodine therapy in adolescent patients with Graves' disease. International Journal of Pediatric Endocrinology 2011: 14, 2011

Thyroid Isthmus Length and Iodine Turnover as Predictors of Successful Radioactive Iodine Therapy in Patients with Graves' Disease. International Journal of Endocrinology 2017: 7354673, 2018

No impact of dietary iodine restriction in short term development of hypothyroidism following fixed dose radioactive iodine therapy for Graves' disease. Indian Journal of Endocrinology and Metabolism 19(1): 60-65, 2015

Changes in the incorporation of radioactive iodine by the thyroid of patients with toxic goiter during prolonged therapy with methylthiouracil and com-bined treatment with methylthiouracil and radioactive iodine Abstract only. Terap Arkh 35(12): 129, 1963

Radioactive Iodine As An Indicator In Thyroid Physiology. V. The Use Of Radioactive Iodine In The Differential Diagnosis Of Two Types Of Graves' Disease. Journal of Clinical Investigation 21(1): 31-32, 1942

Adjunctive treatment with propylthiouracil or iodine following radioiodine therapy for Graves' disease. Thyroid 3(4): 269-272, 1993

Salivary gland dysfunction after radioactive iodine (I-131) therapy in patients following total thyroidectomy: emphasis on radioactive iodine therapy dose. Clinical Imaging 39(3): 396-400, 2015

Influence of propylthiouracil and methimazole pre-treatment on the outcome of iodine-131 therapy in hyperthyroid patients with Graves' disease. Journal of International Medical Research 37(2): 576-582, 2009

Hyperparathyroidism after radioactive iodine therapy for Graves disease. Surgery 92(5): 811-813, 1982