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Trypanotolerance in inbred mice: an immunological basis for variation in susceptibility to infection with Trypanosoma brucei



Trypanotolerance in inbred mice: an immunological basis for variation in susceptibility to infection with Trypanosoma brucei



Tropenmedizin und Parasitologie 31(4): 435-438



Previous studies have suggested that the suppression of IgM responses induced by different strains of trypanosomes can be related to the virulence of the parasite in a defined mouse strain (Sacks et al. 1980). This study has examined immunosuppression induced by Trypanosoma brucei NIM7 in two mouse strains (C3H/He and [CBA/H x C57B1/6]F1) which differ considerably in their ability to survive infections. The results confirm our previous studies in that mice were able to survive infection whilst they maintained at last a residue of their ability to mount an IgM response to DNP-Ficoll, a T-independent antigen. Complete abrogation of the IgM response coincided with fulminating parasitaemia, resulting in the death of the host.

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Accession: 044872251

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PMID: 7233540


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