Unscheduled synthesis induced by thiophosphamide in human lymphocytes

Titenko, N.V.

Tsitologiia i Genetika 17(2): 58-62

1983


ISSN/ISBN: 0564-3783
PMID: 6407162
Accession: 044901822

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Abstract
An unscheduled DNA synthesis in human nonreplicative lymphocytes is shown to follow cell exposure to thiophosphamide at a dose level of 1-10 microgram/ml. Incorporation of 3H-thymidine in the absence of the mutagen is probably due to spontaneous reparative processes. Significant variations are found of spontaneous and thio-phosphamide-induced levels of a reparative DNA synthesis in normal individuals.