+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Virus elimination in acute lymphocytic choriomeningitis virus infection. Correlation with virus-specific delayed-type hypersensitivity rather than cytotoxicity

Virus elimination in acute lymphocytic choriomeningitis virus infection. Correlation with virus-specific delayed-type hypersensitivity rather than cytotoxicity

Scandinavian Journal of Immunology 17(6): 489-495

The immunological effector mechanism responsible for the elimination of virus in murine acute non-fatal extracranial lymphocytic choriomeningitis virus infection was studied. In this infection virus clearance is generally regarded as the result of a direct action of virus-specific cytotoxic T cells (Tc cells) on virus-producing target cells in the infected mouse. However, by manipulating the antiviral immune response by pretreatment with various doses of cyclophosphamide, we found lack of correlation between Tc-cell activity and the clearance of virus. In contrast, we observed a conspicuous correlation between the host's ability to mount a virus-specific delayed-type hypersensitivity (DTH) response and its capacity to combat virus. Moreover, pretreatment with silica and carrageenan prolonged viraemia without impairment of the peak Tc-cell response. These findings indicate that Tc cells have little or no capacity to eliminate virus, at least in the absence of an inflammatory response, and our findings suggest that virus clearance reflects a DTH-like process.

Please choose payment method:

(PDF emailed within 0-6 h: $19.90)

Accession: 044960884

Download citation: RISBibTeXText

PMID: 6603010

DOI: 10.1111/j.1365-3083.1983.tb00816.x

Related references

Mechanism of recovery from acute virus infection. IX. Clearance of lymphocytic choriomeningitis (LCM) virus from the feet of mice undergoing LCM virus-specific delayed-type hypersensitivity reaction. Journal of General Virology 70: 3305-3316, 1989

Virus elimination in acute lymphocytic choriomeningitis virus infection correlates with virus specific delayed typed hyper sensitivity rather than cyto toxicity. Scandinavian Journal of Immunology 16(5): 451, 1982

T cell effector function and unresponsiveness in the murine lymphocytic choriomeningitis virus infection i. on the mechanism of a selective suppression of the virus specific delayed type hypersensitivity response. Scandinavian Journal of Immunology 24(2): 127-136, 1986

Fatal meningitis following lymphocytic choriomeningitis virus infection reflects delayed-type hypersensitivity rather than cytotoxicity. Scandinavian Journal of Immunology 17(2): 139-145, 1983

Mechanism of recovery from acute virus infection. VIII. Treatment of lymphocytic choriomeningitis virus-infected mice with anti-interferon-gamma monoclonal antibody blocks generation of virus-specific cytotoxic T lymphocytes and virus elimination. European Journal of Immunology 19(7): 1283-1288, 1989

Virus-specific delayed-type hypersensitivity (DTH). Cells mediating lymphocytic choriomeningitis virus-specific DTH reaction in mice. Journal of Immunology 144(5): 1926-1934, 1990

High dose survival in the lymphocytic choriomeningitis virus infection is accompanied by suppressed delayed type hypersensitivity but unaffected t cell cytotoxicity. Scandinavian Journal of Immunology 21(1): 81-92, 1985

H-2 restriction of virus-specific T-cell-mediated effector functions in vivo. II. Adoptive transfer of delayed-type hypersensitivity to murine lymphocytic choriomeningitis virus is restricted by the K and D regions of H-2. Journal of Experimental Medicine 144(3): 776-786, 1976

Lymphocytic choriomeningitis virus-specific delayed-type hypersensitivity reaction in mice. Advances in Experimental Medicine and Biology 257: 91, 1989

Virus specificity of cytotoxic T lymphocytes generated during acute lymphocytic choriomeningitis virus infection: role of the H-2 region in determining cross-reactivity for different lymphocytic choriomeningitis virus strains. Journal of Virology 51(1): 34-41, 1984

The effect of lymphocytic choriomeningitis virus-induced suppression of the delayed-type hypersensitivity reaction on virus clearance and pathogenicity. Medical Microbiology and Immunology 175(2-3): 129-131, 1986

Formation and antiviral function of delayed-type hypersensitivity in mice after infection with the lymphocytic choriomeningitis virus. Koehler, W, Rott, R, Nova Acta Leopoldina; Pathogenicity mechanisms of viral, bacterial and protozoal infections, Nova Acta Leopoldina; Pathogenitaetsmechanismen viraler, bakterieller und protozoaerer Infektionen: 61-77, 1991

Recovery from acute virus infection. Role of cytotoxic T lymphocytes in the elimination of lymphocytic choriomeningitis virus from spleens of mice. Annals of the new York Academy of Sciences 532: 238-256, 1988

Evidence for the presence of T lymphocytes mediating lymphocytic choriomeningitis virus-specific delayed-type hypersensitivity in meningeal infiltrates of infected mice. Annales de L'institut Pasteur / Virologie 134(3): 309-314, 1983

MHC and non-MHC genes regulate elimination of lymphocytic choriomeningitis virus and antiviral cytotoxic T lymphocyte and delayed-type hypersensitivity mediating T lymphocyte activity in parallel. Journal of Immunology 142(4): 1333-1341, 1989