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Virus specificity of cytotoxic T lymphocytes generated during acute lymphocytic choriomeningitis virus infection: role of the H-2 region in determining cross-reactivity for different lymphocytic choriomeningitis virus strains


, : Virus specificity of cytotoxic T lymphocytes generated during acute lymphocytic choriomeningitis virus infection: role of the H-2 region in determining cross-reactivity for different lymphocytic choriomeningitis virus strains. Journal of Virology 51(1): 34-41

We have compared the relatedness of five different strains of lymphocytic choriomeningitis virus (LCMV) as assessed by LCMV-specific cytotoxic T lymphocytes (CTL). Several different mouse strains were injected with each of the five LCMV strains, and the cross-reactivity of virus-specific CTL generated during the acute infection was tested by killing on a panel of target cells infected with the various LCMV strains. We found that the cross-reactivity pattern of LCMV-specific CTL generated in mice of H-2d haplotype (BALB/c WEHI and DBA/2) was strikingly different from that in mice of H-2b haplotype (C57BL/6 and C3H.Sw/Sn), suggesting that the fine specificity of LCMV-specific CTL is a function of the H-2 region. The characteristic cross-reactivity patterns were also observed in (C57BL/6 X DBA/2)F1 mice, demonstrating that the repertoire of the H-2b- and H-2d-restricted LCMV-specific CTL is not changed as a result of complementation by gene products of the other major histocompatibility haplotype. Studies with congenic BALB.B10 and (BALB.B10 X BALB/c)F1 mice firmly established that the characteristic cross-reactivity patterns of LCMV-specific CTL map to the H-2 region and are not influenced by background genes outside the major histocompatibility locus. These results suggest that LCMV determinants seen in the context of H-2d-restricting elements are different from those seen in the context of H-2b-restricting elements. Moreover, our studies show that CTL can be used as probes for dissecting differences among various LCMV strains, but the degree of relatedness between the different LCMV strains is not absolute when measured by CTL recognition. Since the H-2 region regulates the fine specificity of CTL generated during LCMV infection in its natural host, the degree of cross-protective immunity developed during a viral infection apparently depends on the major histocompatibility haplotype. The importance of these findings lies in understanding susceptibility or resistance of various host populations to viral infections and in designing vaccination programs to provide immunity.

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Accession: 044961142

PMID: 6610062

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Qian, G.; Jin, F.; Chang, L.; Yang, Y.; Peng, H.; Duan, C., 2012: NIRF, a novel ubiquitin ligase, interacts with hepatitis B virus core protein and promotes its degradation. Hepatitis B virus (HBV) core protein (HBc) is a major component of viral nucleocapsid and a multifunctional protein involved in viral maturation and release. It is unstable and present in cells at low level because of K96 lysine residue, which is...

Zhezhel N. F.; Zhezhel Yu N., 1977: The covariance characteristics of the algorithms of random fields. Leningrad, Universitet, Uchenyye Zapiski, Fizicheskiy i Geologicheskiy Fakul'tety, Seriya Fizicheskikh i Geologicheskikh Nauk 391, Vypusk 26, Voprosy geofiziki): 185-190

Sullivan W.R.; Fox K.E., 1988: Gas chromatographic determination of the high ceiling diuretic ethacrynic acid and its thiol adducts in plasma of guinea pigs. Journal of Chromatography Biomedical Applications 425(2): 396-401

Reaves, Robertr, 2001: Water audits: programmed savings. Landscape Management 40(1): 8

Fookes, B.H., 1980: The physiotherapist in functional psychiatry. PhysioTherapy 66(12): 405-407

Flowers T.J.; Dessimoni Pinto C.M., 1970: The effects of water deficits on slices of beetroot d and potato d tissue part 1 tissue water relationships. Journal of Experimental Botany 21(68): 746-753

Ali, M.; Cerskus, A.L.; Zamecnik, J.; McDonald, J.W., 1977: Synthesis of prostaglandin D2 and thromboxane B2 by human platelets. Thrombosis Research 11(4): 485-496

Sick H., 1967: Bico de ferro overlooked seedeater from rio de janeiro brazil sporophia fringillidae aves biology. Anais da Academia Brasileira de Ciencias 39(2): 307-314

Capitoli, RR.; Ortega, EL., 1993: Contribuicao ao conhecimento do espectro trofico de Cyrtograpsus angulatus Dana nas enseadas vegetadas de aguas rasas da Lagoa dos Patos, RS Brasil. Nauplius, 1: 81-87 No unico

Antia, N.H.; Pandya, S.S.; Dastur, D.K., 1970: Nerves in the arm in leprosy. 1. Clinical, electrodiagnostic and operative aspects. International Journal of Leprosy and Other Mycobacterial Diseases 38(1): 12-29