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Beta-Adrenergic regulation of alpha 2-adrenergic receptors in the central nervous system

Beta-Adrenergic regulation of alpha 2-adrenergic receptors in the central nervous system

Science 207(4431): 645-647

ISSN/ISBN: 0036-8075

PMID: 6101510

DOI: 10.1126/science.6101510

Incubation of rat cerebral cortical slices with the beta-adrenergic agonist isoproterenol causes an increase in alpha 2-adrenergic receptor binding in addition to a decrease in beta-adrenergic receptor binding. The effects are rapid and reversible, show a parallel time course, and are blocked by sotalol, a beta-adrenergic receptor antagonist. The beta-mediated regulation of alpha 2-receptor sensitivity at brain norepinephrine synapses may be a mechanism for the homeostatic control of central noradrenergic activity.

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Accession: 044997492

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