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A case of breast cancer with multiple metastases successfully treated by medroxyprogesterone acetate with intermittent intra-arterial infusion low-dose chemotherapy to hepatic metastasis

Kusama, M.; Kaise, H.; Nakayama, S.; Oota, D.; Shimizu, H.; Aoki, T.; Koyanagi, Y.

Gan to Kagaku Ryoho. Cancer and ChemoTherapy 27(14): 2243-2247

2000

ISSN/ISBN: 0385-0684
PMID: 11142170
Accession: 045035383
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A 48-year-old woman who underwent breast-conserving therapy for left breast cancer developed bone, pleural, and liver metastases with local recurrence. The result was an improvement in each image with a marked improvement as seen by elevated tumor marker levels, with treatment by MPA (800 mg/day p.o.) and intermittent low-dose chemotherapy with hepatic arterial infusion. The side effects were acceptable. Normalization of imagings and an improvement in tumor markers continued for two years. Thus, in spite of being a palliative treatment, hepatic arterial infusion chemotherapy for liver metastasis from breast cancer might lead to prolongation of survival because of the improvement of other metastases due to the increased passage effect with MPA.

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