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A new bioabsorbable intravascular stent: in vitro assessment of hemodynamic and morphometric characteristics

A new bioabsorbable intravascular stent: in vitro assessment of hemodynamic and morphometric characteristics

Journal of Interventional Cardiology 5(3): 187-194

Currently available intracoronary stents are permanent and their placement may be complicated by thrombosis and restenosis. We have developed a new bioresorbable stent constructed of type I collagen. This stent has a compliant tubular structure that is self expanding and carries a net negative surface charge to increase hemocompatibility. In vitro histologic and morphometric examination was performed by deploying the stent in six pressure fixed explanted porcine arteries. Morphometry revealed a close relationship between the stent external diameter 2.9 +/- 0.4 mm) and the arterial lumen diameter (3.0 +/- 0.4 mm). A relative reduction in arterial lumen diameter secondary to stent placement of 17% to 26% was observed. Folding of the stent wall was noted in those preparations where the stent external diameter was larger than the arterial lumen diameter. Polyvinyl chloride (PVC) tubing was used as a mock arterial segment for flow studies. Flow at baseline and following stent placement was determined at perfusion pressures of 10, 50, and 80 mmHg. A modest reduction in flow following stent placement of between 2% and 6% was observed. Thus, type I collagen may be used to construct a self expanding tubular stent. Morphometric and hemodynamic evaluation reveals a modest impact on arterial lumen dimensions and flow.

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Accession: 045079057

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PMID: 10150958

DOI: 10.1111/j.1540-8183.1992.tb00426.x

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