+ Site Statistics
References:
54,258,434
Abstracts:
29,560,870
PMIDs:
28,072,757
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

A new bioabsorbable intravascular stent: in vitro assessment of hemodynamic and morphometric characteristics



A new bioabsorbable intravascular stent: in vitro assessment of hemodynamic and morphometric characteristics



Journal of Interventional Cardiology 5(3): 187-194



Currently available intracoronary stents are permanent and their placement may be complicated by thrombosis and restenosis. We have developed a new bioresorbable stent constructed of type I collagen. This stent has a compliant tubular structure that is self expanding and carries a net negative surface charge to increase hemocompatibility. In vitro histologic and morphometric examination was performed by deploying the stent in six pressure fixed explanted porcine arteries. Morphometry revealed a close relationship between the stent external diameter 2.9 +/- 0.4 mm) and the arterial lumen diameter (3.0 +/- 0.4 mm). A relative reduction in arterial lumen diameter secondary to stent placement of 17% to 26% was observed. Folding of the stent wall was noted in those preparations where the stent external diameter was larger than the arterial lumen diameter. Polyvinyl chloride (PVC) tubing was used as a mock arterial segment for flow studies. Flow at baseline and following stent placement was determined at perfusion pressures of 10, 50, and 80 mmHg. A modest reduction in flow following stent placement of between 2% and 6% was observed. Thus, type I collagen may be used to construct a self expanding tubular stent. Morphometric and hemodynamic evaluation reveals a modest impact on arterial lumen dimensions and flow.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 045079057

Download citation: RISBibTeXText

PMID: 10150958

DOI: 10.1111/j.1540-8183.1992.tb00426.x


Related references

Deformation characteristics of a bioabsorbable intravascular stent. Investigative Radiology 27(12): 1020-1024, 1992

Assessment of the absorption process following bioabsorbable everolimus-eluting stent implantation: temporal changes in strain values and tissue composition using intravascular ultrasound radiofrequency data analysis. A substudy of the ABSORB clinical trial. Eurointervention 4(4): 443-448, 2009

Coronary bioabsorbable magnesium stent: 15-month intravascular ultrasound and optical coherence tomography findings. European Heart Journal 28(19): 2319-2319, 2007

Intravascular ultrasound assessment of optimal stent area to prevent in-stent restenosis after zotarolimus-, everolimus-, and sirolimus-eluting stent implantation. Catheterization and Cardiovascular Interventions 83(6): 873-878, 2015

Optical coherence tomography and intravascular ultrasound imaging of bioabsorbable magnesium stent degradation in porcine coronary arteries. Cardiovascular Revascularization Medicine 9(4): 248-254, 2008

Monitoring in vivo absorption of a drug-eluting bioabsorbable stent with intravascular ultrasound-derived parameters a feasibility study. Jacc. Cardiovascular Interventions 3(4): 449-456, 2010

Early- and long-term intravascular ultrasound and angiographic findings after bioabsorbable magnesium stent implantation in human coronary arteries. Jacc. Cardiovascular Interventions 2(4): 312-320, 2009

Intravascular ultrasound assessed incomplete stent apposition and stent fracture in stent thrombosis after bare metal versus drug-eluting stent treatment the Nordic Intravascular Ultrasound Study (NIVUS). International Journal of Cardiology 168(2): 1010-1016, 2014

Assessment of optimum stent deployment by stent boost imaging: comparison with intravascular ultrasound. Heart and Vessels 28(1): 1-6, 2013

Intravascular ultrasound assessment of sirolimus-eluting stent restenosis or thrombosis after stent implantation. Zhonghua Xin Xue Guan Bing Za Zhi 37(5): 397-401, 2010

Serial intravascular ultrasound assessment of very late stent thrombosis after sirolimus-eluting stent placement. Journal of Cardiology 64(4): 279-284, 2015

Comparison of optical coherence tomography and intravascular ultrasound for the assessment of in-stent tissue coverage after stent implantation. Eurointervention 5(5): 538-543, 2010

Mechanisms of coronary in-stent restenosis Neointimal proliferation or stent compression? Serial assessment by intravascular ultrasound. Circulation 88(4 PART 2): I598, 1993

Intravascular ultrasound assessment of intimal hyperplasia after coronary stent implantation in humans implications for the mechanisms of in stent restenosis. Circulation 84(4 SUPPL): II721, 1991

Volumetric intravascular ultrasound assessment of neointimal hyperplasia and nonuniform stent strut distribution in sirolimus-eluting stent restenosis. American Journal of Cardiology 98(12): 1559-1562, 2006